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The Role of PGF2a in Muscle Growth

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    Prostaglandins are an essential part of the substances known as eicosanoids. Nevertheless, eicosanoids are a particular group of substances that sourced out from fatty acids. Also, known to include leukotrienes, thromboxanes, and prostaglandins. These formed from the precursor fatty acids with oxygen atoms incorporated into the fatty acid chains.

          This also specifically carried out by the cyclooxygenase enzymes. The metabolites of prostaglandins found in the tissues of the body.

Prostaglandins Discovered In The Year of 1930:

     Prostaglandins discovered including their structure in the year of 1930. New York gynecologists have observed that the seminal fluid of humans stimulates the contraction of the isolated uterine muscle.

       Then confirmed in a report that the seminal fluid produces contraction in the intestinal smooth muscle. This is also mainly responsible for lowering the blood pressure after being injected into the bloodstream.

Prostaglandins Role in The Body:

        Prostaglandins have their essential role to play in the body. They are basically classified as the autocrine and paracrine regulators.

          Actually, they do not fit into the classification of hormones. One thing you will need to understand is that they are a corollary of the so-called endocrine system.

PGF2a Increases The Signaling Pathways of Calcium and Intracellular Calcium:

 

       PGF2a also, known to increase the signaling pathways of calcium and intracellular calcium. These are somehow essential as part of the many different stages of myogenesis that help in the success of muscle growth. Further hypothesized that the PGF2acould regulate the growth of the skeletal muscles.

        However, the growth brought by PGF2acomes out via an NFAT-dependent pathway. Prior to these data, these only implicate a novel function for the PGF2ain the growth of the skeletal muscles. However, there is also a novel intersection between NFAT signaling pathways and prostaglandin.

PGF2a Increases The Nuclear Number and Muscle Cell Size:

       The hypothesis suggesting that PGF2ahaving an essential role to play in the growth of muscle cells involved the differentiation of the main muscle cultures. They were treated with PGF2adoses or a synthetic analog of the PGF2a.

    After twenty-four hours, most of the cells have been differentiated. They have also been known to form several multinucleated cells.

     Even if there is no such thing as a difference seen between the drug-treated and vehicle-groups at twenty-four hours, after forty-eight hours, the myotubes that were treated with a drug are bigger in size than the vehicle. This only suggested the fact that PGF2acould regulate muscle growth.

PGF2aIncreases The Size of Myotube:

       PGF2aincreases the size of myotube as it facilitates the fusion of muscle cells. In the fusion of the myoblasts, it creates a multinucleated cell. The growth of cell occurs by way of the fusion of various muscle cells with a nascent myotube.

         This increases the cell size and the myonuclear number. In the treatment of 10-6  M PGF2a, an increase occurred in the myotubes percentage with 5 or even more nuclei. There was also a parallel decrease in the so-called percentage of myotubes with 2 to 4 nuclei.

          Prior to this dose, shown to bring out maximal effects using smooth muscle and cardiac cells. The data suggested that it could increase cell fusion with the myotubes that help facilitate an increase in the size of the muscle cell.

The Mediated Muscle Growth of PGF2aOccurs Via FP Receptor:

        In determining the role of endogenous PGF2a in regulating the myonuclear accretion, cells were applied with a competitive and selective FP antagonist.

         In that data released, it suggested that PGF2a muscle growth induced is mediated by way of an FP receptor. And, the endogenous PGF2a needs for the growth of muscles.

PGF2a Increases the Myotube Size by Way of a Dependent Pathway of NFAT:

         The main myoblasts actually infected by way of a control retrovirus or a retrovirus that expresses VIVIT. The NFAT transcriptional activity further analyzed in the cells that contain an NFAT responsive luciferase reporter construct.

         The activity of a luciferase further increased in the cells that treated with the 10-6 M PGF by ninefold. The combination of these data highlights that PGF2aactivates the NFAT signaling in the skeletal muscle.

PGF2a Induces the Growth of Muscles:

       PGF2ainduces the growth of muscles. And, the specific agonist of FP receptor can activate an increase in the nuclear number and myotube size that is the same with PGF2a.  The growth of muscles inhibited by the AL-8810 which is a particular FP receptor antagonist.

Other Studies Demonstrate PGF2a:

        There are also other studies that demonstrated PGF2aand its role in increasing protein synthesis in the skeletal muscle cells. It also further activates both protein synthesis and cell fusion. This could also regulate hypertrophy of the skeletal muscles.

         Now, you have learned the role of PGF2a in muscle growth!

Must Read Our Article: Top Natural Oral Steroids to Supercharge Your Muscle Growth

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Bodybuilding

Calorie Dumping: A Bodybuilder’s Guide

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"Calorie dumping" in bodybuilding refers to a strategy where an individual consumes a large number of calories in a single meal, often following a period of low-calorie intake.

This practice is believed to support muscle growth by providing a surplus of energy and nutrients.

The idea is that after a period of restricted calorie intake, the body becomes more efficient at utilizing nutrients, making it more receptive to absorbing and utilizing the surplus calories in a short period.

However, this approach may not suit everyone and should be approached cautiously as it can lead to discomfort and potential digestive issues.

Calorie dumping, also known as refeeding or cycling calories, is sometimes preferred by bodybuilders to help prevent metabolic adaptation and aid in breaking through plateaus.

By occasionally consuming higher calorie levels, they aim to boost metabolism, replenish glycogen stores, and maintain hormone balance for better muscle growth and fat loss in the long term.

Bodybuilders focus on controlled nutrition plans to optimize muscle growth and minimize fat gain. However, occasionally, you might increase the calorie intake temporarily before an intense workout or competition to boost energy levels, but this isn't considered calorie dumping in the traditional sense.

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Long-term and Short-term Benefits of Calorie Dumping

Short-term benefits include replenishing glycogen stores, boosting metabolism, and providing mental relief from a strict diet.

Also known as a "refeed" or "cheat day," bodybuilders do calorie dumping for several long-term reasons:

Best Foods for Calorie Dumping

Foods that are high in protein and low in fat can be great for bodybuilders for calorie dumping. Chicken breast, turkey, fish, tofu, egg whites, and low-fat dairy are good options.

Vegetables like broccoli, spinach, and peppers can also be helpful due to their low calorie content and high nutritional value.

There are some foods that can be great for calorie dumping for bodybuilders:

  1. Chicken Breast: High in protein, low in fat, and versatile in cooking methods.
  2. Turkey: Lean protein source aiding muscle building and repair.
  3. Fish (Salmon, Tuna): Rich in omega-3 fatty acids and high-quality protein.
  4. Egg Whites: Low in calories, high in protein, and versatile for various dishes.
  5. Tofu: Plant-based protein source with minimal fat content.
  6. Low-Fat Dairy (Greek Yogurt, Cottage Cheese): High protein, low-fat options aiding muscle recovery.
  7. Broccoli: Low in calories, high in fiber, and rich in vitamins and minerals.
  8. Spinach: Nutrient-dense green, packed with iron, vitamins, and antioxidants.
  9. Bell Peppers: Low-calorie vegetable loaded with vitamin C and other antioxidants.
  10. Quinoa: High-protein grain alternative with a good balance of essential amino acids.

These foods offer a mix of high-quality protein, essential nutrients, and are relatively low in calories, making them ideal for bodybuilders looking to manage their calorie intake while supporting muscle growth and recovery.

However, managing calorie intake and expenditure is crucial. For bodybuilders aiming to manipulate their body composition, a structured routine combining resistance training, cardiovascular exercise, and a controlled diet is essential.

Tailoring calorie intake to support muscle growth while maintaining a caloric deficit (if aiming for fat loss) or surplus (for muscle gain) is key. Consulting a nutritionist or a fitness professional can help create a personalized plan aligned with specific fitness goals.

Calorie Dumping At Night or Daytime?

When Is Calorie Dumping Considered Inappropriate?

One should avoid calorie dumping when they are in a bulking phase aiming to gain muscle mass. During this phase, consistent calorie intake is crucial to support muscle growth.

Calorie dumping, or suddenly dropping caloric intake too low, can hinder muscle development and potentially lead to a loss of muscle mass.

Calorie Dumping VS. Calorie Cycling

Bodybuilders often use "calorie cycling" instead of calorie dumping. It is a strategy that involves varying your calorie intake throughout the week, alternating between high, moderate, and low-calorie days.

The technique is used to support muscle growth while managing body fat. It helps prevent metabolic adaptation, keeps the body from plateauing, and can aid in maintaining a higher metabolic rate. By manipulating calorie intake strategically, it's possible to optimize muscle retention during fat loss phases and support overall performance.

Calorie Dumping VS Reverse Dieting

Another method is "reverse dieting," gradually increasing calorie intake after a certain period. Focus on nutrient-dense foods, proper macronutrient distribution, and mindful eating to support performance and muscle growth without resorting to calorie dumping.

The goal is to minimize fat gain while boosting metabolism and restoring hormone levels.

It involves incrementally adding calories back into your diet over time, typically in small increments each week, to allow the body to adapt to higher food intake without excessive weight gain.

This approach helps prevent rapid weight regain, supports metabolic health, and can aid in maintaining a healthier balance in the body post-competition or intense dieting phases.

More Ways to Increase Calories Intake

As a bodybuilder, you need to know when it's necessary to up your calories intake.

Those aiming to increase calorie intake should employ strategies like consuming calorie-dense foods (nuts, nut butter, avocados), incorporating more frequent meals, adding healthy fats, opting for larger portions of protein and carbohydrates, utilizing protein shakes or weight gainers, and being mindful of nutrient timing to fuel workouts efficiently.

Tracking intake and gradually increasing calories is key to controlled growth and energy provision for intense workouts.

Overall

Bodybuilders should be aware that this phenomenon can occur after a period of reduced calorie intake, causing a temporary decrease in weight that may be mistaken for significant fat loss.

It's important to differentiate between actual fat loss and transient changes to avoid discouragement or misinterpretation of progress. Staying consistent with a well-balanced diet, adequate hydration, and sustainable training is crucial for long-term success in bodybuilding.

Are you looking for supplements and potential steroids to help with muscle growth? Etalaze.biz is the ultimate store to get quality bodybuilding products at discounted rates. Check in today and secure yourself the best holiday offer.

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Beginners

Tren Cycle for Beginners

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Bodybuilders must have a clear approach to the tren cycle for beginners. Trenbolone is a potent steroid that should be cautiously and properly researched.

For beginners, starting with a lower dosage and gradually increasing it over time is recommended. This allows the body to adjust to the effects of trenbolone and helps minimize the risk of potential side effects.

Start With A Plan

It is also important to have a well-structured cycle plan in place. This includes determining the cycle duration, dosages, and frequency of administration. Consulting with a knowledgeable healthcare professional or experienced trainer can provide valuable guidance in creating an effective cycle plan.

Additionally, proper nutrition and training protocols are essential during a trenbolone cycle. A balanced diet of protein, carbohydrates, and healthy fats will support muscle growth and recovery. Combined with an appropriate workout routine tailored to individual goals, this can maximize the benefits of the trenbolone cycle. Remember that safety should always be a priority when using any steroid.

Educating oneself about potential side effects, risks, and proper usage guidelines is crucial before embarking on a trenbolone cycle or any other steroid regimen. You're right! Proper nutrition and training protocols are crucial when using trenbolone or other steroid. A balanced diet is important to provide the necessary nutrients for muscle growth and recovery. Including sources of protein, carbohydrates, and healthy fats can support your body's needs during the cycle.

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Tailor Your Training Routine To Individual Goals

In terms of training, having an appropriate workout routine tailored to your individual goals is key. This can help optimize the benefits of the trenbolone cycle by ensuring that you're targeting specific muscle groups and incorporating exercises that promote strength and hypertrophy.

Dig Out More Information

However, it's important to prioritize safety when using any steroid. Before starting a trenbolone cycle or any other steroid regimen, educating yourself about potential side effects, risks, and proper usage guidelines is essential. This will help you make informed decisions regarding dosage, duration of use, and post-cycle therapy (PCT) to minimize potential risks.

Furthermore, consulting with a healthcare professional or qualified fitness expert with steroid experience can provide valuable guidance throughout your journey. They can monitor your progress, address any concerns or questions you may have. Always remember that responsible use of steroids involves thorough research, consideration of potential risks/benefits ratio, and being mindful of your overall health and well-being.

The Frequency of Tren Cycle for Beginners

When it comes to cycling Trenbolone, there are several factors to consider. The frequency of the Tren cycle for beginners can vary depending on individual goals, experience level, and tolerance to the compound. Typically, Trenbolone cycles range from 8 to 12 weeks in length. However, some advanced users may extend their cycles up to 16 weeks.

It's important to note that Trenbolone is known for its strong side effects, including potential cardiovascular strain, suppression of natural testosterone production, and liver toxicity. Therefore, using this steroid responsibly and following proper cycling protocols is crucial.

Many experienced users recommend starting with a lower dosage during the first cycle to assess how your body responds to Trenbolone. Incorporating post-cycle therapy (PCT) after completing a Trenbolone cycle is also advisable to help restore hormonal balance and minimize potential side effects.

Ultimately, beginners' frequency of the tren cycle should be determined based on individual goals, understanding of the compound's risks and benefits, and consultation with a knowledgeable healthcare professional or experienced steroid user.

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Tren Cycle for Beginners Steps

When using trenbolone (tren) for beginners, it is important to understand the step-by-step procedure clearly. Tren is a powerful anabolic steroid that should be cautiously approached, especially for those new to using performance-enhancing substances.

Before starting a tren cycle, it is essential to consult with a healthcare professional or an experienced fitness expert who can provide guidance and monitor your progress throughout the cycle. They can help determine if you are ready for this level of supplementation and ensure your safety.

The step-by-step procedure for a tren cycle typically involves the following:

1. Research and Education: Thoroughly research tren and its potential benefits, risks, and side effects. Understand how it interacts with your body and what precautions must be taken.

2. Establish Goals: Clearly define your goals for using tren, whether it's gaining muscle mass, increasing strength, or improving athletic performance. This will help guide your dosage and duration of the cycle.

3. Dosage Determination: Start with a low dosage to assess how your body reacts to tren. Beginners start with around 50-100mg per week, split into several smaller doses.

4. Cycle Duration: A typical beginner's tren cycle lasts 8-12 weeks. It's important not to exceed this timeframe as prolonged use can increase the risk of side effects.

5. Supportive Supplements: Consider incorporating supplements such as liver support agents or testosterone replacement therapy (TRT) during your cycle to mitigate potential adverse effects on liver function or natural testosterone production.

6. Monitoring Progress: Regularly monitor your progress during the cycle through objective measures such as body composition analysis, strength gains, and overall well-being.

7. Post-Cycle Therapy (PCT): After completing the Tren cycle, implement an appropriate post-cycle therapy protocol to help restore natural hormone production and minimize any potential side effects associated with discontinuing Tren use.

Where to Source Your Tren

When purchasing trenbolone, it is important to prioritize safety and legality. Trenbolone is a controlled substance in many countries, and its sale without a prescription is prohibited. Therefore, being cautious and ensuring you purchase from a reputable source is crucial.

One of the most reliable options for buying trenbolone is through licensed pharmacies with proper prescriptions, such as Etalaze.biz. These pharmacies adhere to strict regulations and quality control measures, ensuring you receive genuine products.

However, it's important to note that using trenbolone for non-medical purposes, such as bodybuilding or performance enhancement, may not be legal in some countries. In such cases, attempting to purchase trenbolone from underground or illicit sources can pose serious risks to your health and legal consequences.

It is always recommended to consult with a healthcare professional or an authorized medical practitioner who can guide you on the appropriate usage and legal avenues for obtaining trenbolone based on your specific circumstances.

Tren Cycle for Beginners Take Away

Beginner bodybuilders need to understand the approved dosage guidelines when using trenbolone, a powerful anabolic steroid. Trenbolone is known for its potency and effectiveness in promoting muscle growth and strength gains. However, it is crucial to cautiously approach Tren Cycle for Beginners due to its strong nature.

For beginners, starting with a lower dosage of trenbolone is generally recommended to assess their tolerance and response to the compound. The approved dosage for beginner bodybuilders typically ranges from 50mg to 100mg per week. This conservative approach allows individuals to gradually introduce trenbolone into their system while minimizing the risk of potential side effects.

It is important to note that every individual may respond differently to trenbolone, and factors such as age, weight, fitness level, and overall health should be considered when determining the appropriate dosage. It is always advisable for beginners to consult with a knowledgeable healthcare professional or experienced coach who can provide personalized guidance based on their specific circumstances.

Additionally, regardless of experience level, it is crucial for all users of trenbolone or any other anabolic steroid to prioritize proper cycle support and post-cycle therapy (PCT) protocols. These measures help mitigate potential side effects and ensure a safer and more effective experience with trenbolone.

In conclusion, when using trenbolone as a beginner bodybuilder, adhering to approved dosage guidelines ranging from 50mg-100mg per week is essential. Consulting with healthcare professionals or experienced coaches can provide valuable insights tailored to individual needs. Prioritizing cycle support and PCT protocols further contributes to optimizing safety and effectiveness during the usage of this potent anabolic steroid.

Related Article: Beginner Steroid Cycles To Do

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Bodybuilding

Olympic Lifting : 25 Strategies That Work

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The Olympics is one of the most excellent sports we have today. The worldwide event originated in Greece centuries ago. It was initially a reserve for the Greeks and has since expanded, and countries hold the event on a rotational basis. Until recently, the Olympics happened annually, but we now have summer and winter Olympics. You're mistaken if you think the Olympics is all about racing. Many events take place, including fitness. The Olympic lifting competition is quite competitive; only the best make it to the top. For this reason, we are equipping you with some of the best strategies to beat your opponents in the Olympics and other bodybuilding contests.

Olympic lifting is not necessarily a sport in the Olympics but a bodybuilding category. It involves snatching the barbell from the floor and lifting it above the head. Here are strategies that should help you to master Olympic lifting.

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Explained 

Grip Matters In Olympic Lifting

The grip is everything when it comes to Olympic lifts. Make sure to hold the barbell firmly to engage your back. You need to rotate your shoulders as you lift the load to achieve this. A firm grip enhances your stamina and ensures you don't run into unnecessary accidents. As you do the lifting, endure your shoulders at the same level as the hips and legs slightly apart.

Know Your Competitors

You don't necessarily have to compete against someone else regarding Olympic lifts. While most professional bodybuilders compete to beat opponents, some people are there to beat their previous records. The most important thing is to know what you want and work towards achieving your goal.

Stabilize Before Olympic Lifting

As mentioned, stability is of the essence before lowering yourself to lift that barbell. Plant your feet firmly on the floor and make your hands long. Ensure the hips, back, and shoulders are in pretension before going down. Finally, take a deep breath and grip that barbell like a pro.

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Clean and Press

The clean and press technique involves spreading the legs slightly beyond the hips. Assume squatting and use your hips, core, and legs to drive the barbell up. At the same time, you should shrug your shoulders a bit to power the lift.

Distribute Weight Evenly 

Lifters who do not achieve the required stability during Olympic lifts have not distributed their weight evenly. The position of the center of gravity plays a vital role when lifting heavy weights. Always ensure it is as low relative to the load level to boost your stability. To achieve this, ensure your core and shoulder are pre-tensioned before the lifting. 

Assume the Proper Posture

Posture is crucial for every lift and repetition regarding Olympic lifting. Watch closely the positioning of your chin, back, hands, and legs before, during, and after every ride. Significantly, your toes should go underneath the bar before you lower yourself to lift it. 

The Muscle Snatch Technique

Few bodybuilders know about this incredible technique that is handy in Olympic lifting. It involves doing high reps with low weights and vice versa. The method shields the lifter from unnecessary strain, as seen with the power snatch technique.

Bar Positioning

The bar's position is another essential factor you need to consider before going for the lift. It must always be close to the body for obvious reasons. The further away it is from you, the lesser your chances of having a firm, stable grip. Never overlook this rule whenever you're doing Olympic lifting. Proximity to the barbell will also make you have a comfortable reception. 

Know Your Snatching Attempts in Olympic Lifting 

Depending on the nature of the lifting, the number of snatch attempts should always be those you can handle. While competitive lifting requires you to have as many attempts as possible, personal beating records should not make you overstretch your limits. 

Clean High Pull

Another essential technique is the clean high pull, an alternative for pulling a solid front. The technique aims to strengthen your core muscles to make subsequent turnovers simpler. 

Watch The Numbers 

Check your number and those of your opponents before the competition kicks off. Checking them not only prepares you psychologically but also gives a glimpse of your competitors. Of course, this is only necessary if you're participating in a bodybuilding contest because it is where you gauge their relative strength. 

Warm-Up Is Key to Strategic Olympic Lifting 

You can do very little to improve strength or muscle during warm-up. However, you could gain a lot more from it than those two. For instance, you are warming up before an Olympic lifting event boosts confidence and sends your adrenaline rushing. The latter should not mean tension but rather being in the perfect mood to unleash the beast within you.

You Need Discipline in Olympic Lifting 

Bodybuilding is a highly demanding sport that requires you to have the best discipline. Discipline ranges from avoiding foods and drinks that don't contribute anything positive to your Olympic lifting to keeping time. You don't have to spend valuable time chatting the day away with your buddies. Use that time to make yourself perfect in Olympic lifting. 

Check Your Squat Pattern for Olympic Lifting

The book does virtually Olympic lifting. You don't have to invent new techniques because nothing hasn't been tested. For instance, the correct squatting pattern involves making your back straight, reducing inward knee collapse, and having the proper depth. 

Muscle Action Timing

Muscles respond differently to the first, second, third, and subsequent pulls. Ensure you adjust accordingly to the muscle reaction to avoid overstretching them. Moreover, underperforming in the initial draws reduces the quality of lifts. Essentially, strive to maintain a balance so you're neither harming your body nor doing below your potential.

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Boost Your Olympic Lifting Flexibility

A static routine is all you need for strength and stability. The stationary practice should be part of your being fully conversant before the actual lifting. 

Outlift the Opposition

The Olympic lifting is all about who lifts the most weight.  Always ensure you're ahead of your opponent or training partner by a kilogram or less. That way, you will teach a competitive culture to help you fare well in any bodybuilding competition. Importantly,  choose your poundage wisely to ensure you have a competitive edge. 

Lower the Barbell Actively

Lifters don't do as much work while lowering the weights as lifting them. But did you know that reducing the barbell is an active movement that involves every muscle in your body? Furthermore, active lowering is a factor judges consider in bodybuilding competitions. 

Train Hard for Olympic Lifting 

There is no better strategy for professional lifting than consistent training. You can't learn everything through observation or reading about it. Get up every day and, take yourself to the gym, do the actual lifting using the correct procedure. Only that way will you master it to perfection. 

Don't Waste Time on Top of the Pull

Every second wasted on top of the pull is a point taken off your record. There's not much strain when the bar is down, but the same cannot be said when it is above your shoulders. Therefore, always act on the barbell when you're in a perfect position. 

Keep Your Shoulders Back

It is the best way to keep your core straight when lifting. Notably, the s rugged, laid-back shoulders will reduce the strain on the muscles in the lower part of the body. 

Do More Strength Training for Olympic Lifting

Strength training is the ultimate secret to all-all-around Olympic lifts. Boost your strength as much as possible before standing before that barbell. Use the right equipment, diet, and supplementation to perform Olympic lifting. 

Join Lifting Classes 

It is rewarding when you do everything like a professional. Instead of trying to learn everything in the streets, why not find yourself a good coach or personal trainer for the same? A good lifting course will cover general physical preparedness, flexibility, mobility,  techniques, and more. 

The Barbell Is Not Everything in Olympic Lifting 

The COVID-19 pandemic has taught us to improvise when things get thick. You can still rain for Olympic lifting even without the barbell. Work on technique and power through maximum strength, peak power, velocity, and speed. 

Overall

Olympic lifting is an integral part of bodybuilding. Every bodybuilder can't run away from it. It is also one of the most technical aspects of the sport. We hope the strategies we have shared will go a long way in preparing you to be one of the best Olympic lifters. Our shop and blog are full of goodies for all your bodybuilding needs. Please feel free to explore. 

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