Steroids

Oral and Injectable Steroids

Published

13 years ago

August 3, 2012

F Kyle

Surely that all bodybuilders know that anabolic steroids have two forms of administration, namely oral and injectable. Both of them have pluses and minuses which we will analyze in this article. Let’s see the specific or oral steroids. Oral steroids have a narrow range of assortment, their number can be counted on fingers. Of course, the most popular of them is well-known Metal and all its analogs like Dianabol, Nerobolum and many others.

Also to this list belongs to another form of the oral steroid called Winstrol/ Stanazolol/Stromba and Primobolan. Add to this list Oximetalon and Andriol capsules and you have here almost all oral steroids. So, let’s describe briefly what are oral steroids. It is known that a simple testosterone cannot be absorbed orally, it is destroyed in the stomach and intestines without having absorbed into the blood. It's been checked hundreds of experiments on the athlete.

Why have been done so many experiments on testosterone? In women is more easily to determine the level of increase of male sex hormones in the blood. This being said, we know that in a man's sperm along with the seminal fluid and sperm is released yet a number of male sex hormone testosterone.

That’s why sports physicians propose athletes immediately before the performance drink this liquid for the sharp rise of the level of hormones in the blood. For this purpose, to the competition have been driven donor men with a great opportunity to allocate sperm. Ok, the way athletes get this liquid is unknown, we can only suppose it, but the truth is that method proved to be useless.

Must Read: Steroids and Sporting Society

All oral steroids are designed at the molecular level so that they are not destroyed in the gut entirely, but are absorbed into the blood. At the same time, the blood passes through the cleaning cycle through the liver, which is the main filter of the body, where the lion's share of the drug is activated.

This is the main cause of death of liver cells as a result of oral steroids use. Many physicians propose to take this type of medication orally keeping it under the tongue, bypassing the stage of purification of blood by the liver. But this method is proved to be uncomfortable and painful.

Related Article: Liver Damage While On Oral Steroids

Oral and Injectable Steroids

Try to walk for about fifteen minutes after the complete dissolution of the tablet under the tongue with a mouth full of nasty saliva. Surely you will not like it, and you will abandon this method after several attempts. Of course, the oral preparations are very convenient to use. Usually, they are chosen by people who are afraid of injections and would never replace this form of steroids.

Another plus, and minus simultaneously of oral medications is that they have a short influence and are rapidly destroyed in the liver and blood. The lifetime of oral steroids is up to 24 hours. For this reason, this type of drugs is used in equal portions during the day to maintain the proper level of hormones in the blood.

Oral steroids are very convenient for athletes who face the competition doping control since oral medications are fast acting and leave the body. So, depending on your body after taking chemistry in 5-10 days, no test can detect in your urine or blood metabolites and hormones themselves.

Also, in the conclusion of this group of steroids have to be mentioned that as a rule, the same steroid in the injectable or oral form in the same dosage differ in strength and duration. Hence according to the opinions of many athletes, the oral form of steroids is weaker than a similar injection. And that, in general, it is logical, because the chemistry of drugs acting differently.

So, Summarizing The Above we Have:

Summarizing

Oral forms of steroids are toxic to the liver, in contrast to their injecting counterparts.
Oral steroids have a very short period, causing a sharp rise and fall of hormone levels in the blood.
Pills have to be taken on the same portions during the day.
Oral steroids are rapidly eliminated from the body. Just a week and you are pure as glass.
This type of steroid is preferred by novices athletes or people who are afraid of injections.

The second one group of steroids is injectable steroids. This group of drugs is the antipode of oral steroids in the majority. Firstly, the range of injectable steroids is much wider and more diverse. Among injectable steroids have to be mentioned Winstrol which is different from all other forms of injectable steroids.

Must Read: Stacking Dianabol with Injectable Steroids

So, if you take some capsules with any anabolic steroids, then you will not notice any fundamental difference to the smell or the light. Why are these mixture so popular worldwide? You have to know that in order for a molecule of testosterone do not be destroyed immediately the blood they are clung to the various types of esters.

The resulting molecular giants are hydrophobic, hence not soluble in water. All this solution is soluble in fat, but naturally, instead of fat fare used natural oils like peanut, peach and apricot oils. After mixing vegetable oils and essential drug compounds are subjected to special cleaning. This kind of cleaning is required to destroy all microorganisms, settled in the solution and removal of all unnecessary foreign particles and suspensions.

But it happens that not you injected the steroid and get covered with a red rash. What is this? This means that your body along dice oil. Have to be noted that this happens sooner or later to any use of chemistry. The factory such a dirty ampule happens to comes one to an average of one hundred.

It happens that the oil is not warmed to the desired temperature and sealed ampoules. Despite this in many cases, all these spoilage steroids are sold on pharmacy. That way you should not buy cheap chemicals and purchase it from a person you have never seen before in your life.

Best of all is to have a permanent drag dealer and purchased only through him. This tandem is very advantageous for both of them: the dealer has a regular customer, and the buyer has quality and pure chemistry.

Must Read: Is buying injectable steroids online safe?

Let’s see how steroid injection works. Once you have made yourself an injection of an oily preparation, it is deposited in the so-called fat depots. Steroid can be stored there for a long time from a couple of days (like Propionate and Primobolan) up to a year (all known Deca).

Must Read: Guide on Injecting Anabolic Steroids

The degree of resorption and the use of the drug depends on ether. The longer the ester side chain is the longer stays in the fat depot preparation. Such dissolved in the fat depot medication is gradually released into the blood. Of course, the blood brings the molecule hormones to all cells in the body, but even it knows that the concentration in the site of steroid injection is always much higher than in other parts of the body.

This thesis confirms the experience of numerous athletes for injecting steroids in the shoulder biceps and triceps, thigh and hip. I noticed a considerable increase in the affected tissues. However, it should be noted that these injections are not always quite pleasant and are painful.

The advantages of such steroids appear immediately. It is rare to receive one to three vials per week. Let's say you do not need to take 6 tablets of methane daily, but you can just stab a bottle of Deca and happy go the whole week before the next injection, and nothing to worry about.

The curve of the rise and fall of the strength of the drug varies among different steroids. If, for example, the same Propionate begins to act after a couple of hours after the injection, then the results of Deca injection appears will be visible within five days. It is clear that injecting steroids are caught on doping tests elementary.

This is especially true for Deca. It can be reached in urine, even half a year after the last injection. The main advantage of injecting drugs is their low toxicity to the liver and kidneys. Even the strongest and most androgenic drugs in injectable form are less dangerous in relation to their oral counterparts.

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So, Summarizing the Above we Have:

Summarizing

Injectable steroids are comfortable and uncomfortable at the same time to use. It is inconvenient for those who fear needles, but convenient that the injection can be done from once a week or more, and do not eat handfuls of pills daily.
The validity of most of injecting steroids is significantly more than their oral counterparts from three days to a month.
Allocation of the drug in the blood from the fat depots is almost uniformly at certain stages. And it is very convenient as regular hormonal explosions in the body even more harmful than a huge dose of the same oral steroids.
Many injectable drugs are easily reached in case of doping control.
Such drugs are straining your liver in the tens or even hundreds of times less than oral steroids.

So, it is clear that injectable steroids are more advantageous for you. Meantime, need to be aware that there are cases when oral steroids are irreplaceable. That’s why many athletes add to their injectable steroid course some oral steroids too.

But if you are an amateur who needs to gain weight, then inject steroids is your path. Forget about oral steroids, whereas your liver is still more important.

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F Kyle

The "GYMRAT" of this blog, Pro-blogger and Fitness Instructor since 2008

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Steroids

Decoding IGF-1 LR3: A Guide to its Benefits

Published

2 weeks ago

April 25, 2025

Sane

IGF-1 LR3 (Insulin-like Growth Factor-1 Long Arg3) is a synthetic variant of IGF-1, a hormone produced by the liver in response to growth hormone (GH). Unlike GH, which works indirectly, IGF-1 directly facilitates the growth and repair of muscle cells.

Related Article: Ostarine for Beginners; The Ultimate Guide

This modified version of IGF-1 is engineered to avoid binding with IGF-binding proteins, extending its half-life to 20–30 hours. As a result, it remains active in the body significantly longer than natural IGF-1.

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Many performance athletes incorporate IGF-1 LR3 post-workout to enhance muscle growth, speed up recovery, and support fat loss. When injected into specific muscle groups, it often produces localized effects. Additionally, it helps with nutrient distribution and, in some cases, improves insulin sensitivity.

On the other hand, human growth hormone (HGH) operates more broadly and indirectly, stimulating the liver to produce IGF-1 and offering more systemic benefits such as improved skin health, joint support, and fat reduction, albeit at a slower pace.

Typical IGF-1 LR3 doses range from 20–50 mcg daily, administered subcutaneously or intramuscularly, often following a workout.

Key Features of IGF-1 LR3

Enhanced Bioavailability: It avoids binding with IGF-binding proteins, increasing its potency.

Muscle Growth & Repair: Directly stimulates muscle cell proliferation and differentiation.

Improved Nutrient Distribution: Helps shuttle nutrients into muscle cells, supporting recovery.

Potential Fat Loss Benefits: Some users report improved insulin sensitivity and fat metabolism.

Mechanism of Action

IGF-1 LR3 interacts with IGF-1 receptors on muscle cells, activating pathways like PI3K-AKT and MAPK, which are crucial for cell growth and regeneration. This makes it a powerful tool for bodybuilders and athletes looking to optimize recovery and muscle development.

What Are the Top 10 Alternatives to IGF-1 LR3?

Here are some of the top alternatives to IGF-1 LR3, each with unique benefits for muscle growth, recovery, and performance:

BPC-157 – Known for its regenerative properties, it enhances healing and tissue repair.

CJC-1295 – A growth hormone-releasing peptide that boosts GH levels for muscle development.

Ipamorelin – Stimulates GH release with minimal side effects, making it a safer option.

MK-677 (Ibutamoren) – A potent GH secretagogue that promotes muscle growth and fat loss.

Sermorelin – Encourages natural GH production, supporting recovery and lean muscle gains.

Tesamorelin – Primarily used for fat loss, but also aids in muscle preservation.

Follistatin-344 – Inhibits myostatin, allowing for increased muscle hypertrophy.

PEG-MGF (Pegylated Mechano Growth Factor) – Enhances muscle repair and growth post-exercise.

GHRP-6 – Stimulates appetite and GH release, supporting muscle mass gains.

GHRP-2 – Similar to GHRP-6 but with fewer hunger-related side effects.

Each of these peptides has distinct mechanisms and benefits.

Must Read: Are Nootropics a Better Option to AAS?

Potential Risks Associated With IGF-1 LR3

IGF-1 LR3 comes with several potential risks, especially for bodybuilders using it to enhance muscle growth. Here are some key concerns:

Hypoglycemia (Low Blood Sugar) – IGF-1 LR3 increases glucose uptake in muscle cells, which can lead to dangerously low blood sugar levels if not managed properly.

Organ Growth – Since IGF-1 affects all tissues, excessive use may lead to unwanted growth in organs, increasing health risks.

Cancer Risk – IGF-1 plays a role in cell proliferation, and elevated levels have been linked to an increased risk of certain cancers.

Water Retention & Edema – Some users experience bloating and fluid retention, which can affect performance and aesthetics.

Joint Pain & Stiffness – Excessive IGF-1 levels may contribute to joint discomfort due to increased tissue growth.

Cardiovascular Issues – There is some concern that IGF-1 LR3 could contribute to heart enlargement or other cardiovascular complications.

Desensitization – Long-term use may reduce the body's natural IGF-1 production, leading to dependency

Overall

IGF-1 LR3's ability to bypass IGF-binding proteins makes it more potent but also increases the likelihood of desensitization with prolonged use. For those considering it, careful dosing and monitoring are crucial to mitigate side effects.

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Steroids

AOD-9604: The Fat-Burning Peptide Explained

Published

1 month ago

April 9, 2025

Sane

AOD-9604, along with the similar HGH Frag 176-191, is a peptide derived from Growth Hormone that includes only the amino acids in HGH responsible for stimulating fat breakdown, known as lipolysis.

This means that these peptides offer the fat-burning benefits of HGH without its other effects—whether beneficial or adverse—and come at a lower cost.

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Lipolysis refers to the process where fat cells are broken down to be utilized as energy. AOD-9604 promotes accelerated fat loss by increasing the body's use of fat as fuel.

For optimal results, the peptides should be used in a fasted state. AOD-9604 and Frag 176-191 are most effective when administered at a dose of 125-250mcg before bedtime (at least 3-4 hours after eating) and in the morning at the same dose, followed by a fasting period of 3-4 hours, ideally combined with fasted cardio.

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Similar Peptides with Fat-Burning Effect

Here’s a list of 10 peptides similar to AOD-9604, each with a brief description:

Ipamorelin: A growth hormone-releasing peptide (GHRP) that stimulates the natural release of growth hormone, promoting fat loss, muscle growth, and improved recovery without affecting other hormones like cortisol or prolactin.

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CJC-1295: A peptide that increases growth hormone and IGF-1 levels, aiding in fat loss, muscle gain, and improved sleep quality. It has a long half-life, making it convenient for users.

HGH Frag 176-191: A fragment of human growth hormone specifically designed for fat-burning. It targets adipose tissue without the broader effects of full-length HGH.

Tesamorelin: Known for reducing visceral fat, this peptide stimulates the release of growth hormone and is often used for weight management and metabolic health.

BPC-157: While primarily known for healing and recovery, BPC-157 can support fat loss indirectly by improving gut health and reducing inflammation.

Melanotan II: Originally developed for skin tanning, it also has appetite-suppressing properties, making it useful for weight management.

Thymosin Beta-4 (TB-500): Focused on healing and recovery, it can enhance physical performance and indirectly support fat loss through improved activity levels.

GHRP-6: A growth hormone-releasing peptide that boosts appetite and metabolism, aiding in muscle growth and fat loss.

Semaglutide: A GLP-1 receptor agonist that regulates appetite and blood sugar levels, making it effective for weight loss and metabolic health.

MK-677 (Ibutamoren): A growth hormone secretagogue that increases growth hormone and IGF-1 levels, promoting fat loss, muscle gain, and improved recovery.

List of Peptides With a Counteractive Effect Bodybuilders Must Avoid

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Some peptides can inadvertently lead to fat gain due to their effects on metabolism and appetite regulation. Here are a few that bodybuilders might want to avoid or use cautiously:

GHRP-6 – While it stimulates growth hormone release, it also significantly increases appetite, which can lead to excess calorie consumption and fat gain.
IGF-1 LR3 – This peptide enhances muscle growth but can also promote fat storage if not carefully managed with diet and training.
MK-677 (Ibutamoren) – Though technically a growth hormone secretagogue rather than a peptide, it boosts GH levels but often leads to increased hunger and potential fat accumulation.
CJC-1295 with DAC – While effective for muscle growth, its prolonged GH release can sometimes lead to unwanted fat retention if not paired with a strict diet

Overall

AOD-9604, derived from Growth Hormone, stimulates fat-burning by targeting lipolysis—the breakdown of fat for energy. It delivers these benefits without the additional effects of Growth Hormone, making it more cost-effective. For maximum effectiveness, it should be administered in a fasted state, ideally before bed and again in the morning at 125-250mcg doses. Pairing its use with fasting and fasted cardio can further enhance fat loss. Its sole focus is on improving the body’s ability to burn fat efficiently.

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Understanding Trenbolone-Induced Cough (“Tren Cough”)

Published

1 month ago

April 7, 2025

Sane

Trenbolone, a potent anabolic steroid, can sometimes cause “tren cough”—a sudden and intense coughing episode shortly after injection. Although not exclusive to Trenbolone, it is more commonly associated with this substance due to its highly irritant nature.

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Mechanisms Behind Tren Cough

Solvent and Carrier Irritation

Trenbolone formulations often include volatile solvents like benzyl alcohol or benzyl benzoate, which may irritate lung tissues when absorbed quickly into systemic circulation.

Prostaglandin Release

Trenbolone promotes increased production of prostaglandins, particularly PGF2α. This compound triggers contraction in the smooth muscles of the lungs, leading to bronchoconstriction and coughing.

Micro-Oil Embolism

Tiny oil droplets from an injection can reach capillaries and travel to the lungs, causing mild embolic reactions that lead to temporary oxygen deprivation and coughing.

Histamine and Mast Cell Activation

For some individuals, Trenbolone triggers histamine release and mast cell activation, mimicking an allergic response and causing bronchospasms and cough reflexes.

Related Article: Best Syringes for Steroid Injection on Amazon

Using Salbutamol (Albuterol) to Manage Tren Cough

Salbutamol, a widely-used β2-adrenergic receptor agonist, can alleviate tren cough symptoms by:
Relaxing bronchial muscles, easing spasms that cause coughing.
Inhibiting prostaglandin effects, reducing bronchoconstriction associated with PGF2α.
Opening airways, preventing severe respiratory restrictions in susceptible individuals.

Application Methods

Inhaler (Optimal)

Take 1–2 puffs of salbutamol (100–200 mcg) 5–10 minutes before a Trenbolone injection. If coughing occurs afterward, additional puffs can swiftly resolve the issue.

Oral Tablets (Moderate)

Consuming 2–4 mg tablets 30–60 minutes before injection offers slower, longer-lasting relief but may be less effective than inhalation methods.

Nebulizer (Severe Cases)

For individuals with frequent episodes, nebulized doses of 2.5 mg salbutamol can provide substantial relief.

Preventive Measures to Reduce Tren Cough Risk

Inject slowly to minimize systemic absorption and irritant effects.
Split doses to lower reaction severity with smaller quantities.
Opt for ventrogluteal injection sites, which have fewer blood vessels, reducing oil embolism risk.
Choose lower-concentration solutions to lessen irritation, as higher concentrations (e.g., Tren Ace 200 mg/ml) are more likely to provoke reactions.

What Other Steroids Can Induce Coughing?

Here's a curated list of peptides, SARMs, and PEDs that may potentially cause coughing or respiratory irritation in bodybuilders and fitness enthusiasts:

Peptides

IGF-1 LR3 (Insulin-like Growth Factor): Known for its anabolic effects, IGF-1 LR3 can occasionally cause mild respiratory irritation due to systemic absorption.

TB-500 (Thymosin Beta-4): While rare, improper injection techniques or high doses may lead to transient coughing episodes.

GHRP-6 (Growth Hormone-Releasing Peptide): This peptide can stimulate histamine release, potentially leading to bronchospasms and coughing.

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SARMs (Selective Androgen Receptor Modulators)

RAD-140: (Testolone) Some users report throat irritation or coughing, often attributed to solvents used in liquid formulations.

YK-11: Known for its myostatin-inhibiting properties, YK-11 may cause mild respiratory discomfort in sensitive individuals.

LGD-4033 (Ligandrol): Though uncommon, some users experience coughing due to carrier solvents or allergic-like reactions.

PEDs (Performance-Enhancing Drugs)

Boldenone Undecylenate (Equipoise): This injectable steroid can cause “Equipoise cough,” similar to tren cough, due to oil embolism or irritant solvents.

Testosterone Suspension: The water-based formulation may lead to coughing episodes if injected improperly or absorbed rapidly.

Nandrolone Decanoate (Deca-Durabolin): While less common, coughing can occur due to histamine release or systemic irritation.

More Tips to Minimize Coughing Risks

Use proper injection techniques to avoid embolic reactions.
Opt for lower-concentration solutions to reduce irritant effects.
Consider antihistamines or bronchodilators for individuals prone to respiratory sensitivity.

Are There Alternatives to Cough-inducing Steroids?

Here are some alternatives to cough-inducing steroids that can provide similar anabolic effects while minimizing respiratory irritation:

Peptides

IGF-1 LR3 (Insulin-like Growth Factor)

Promotes muscle growth and recovery without the irritant properties of certain steroids.

TB-500 (Thymosin Beta-4)

Enhances tissue repair and reduces inflammation, making it a safer option for recovery.

BPC-157 (Body Protection Compound)

Known for its healing properties, it supports muscle repair and joint health.

SARMs (Selective Androgen Receptor Modulators)

RAD-140 (Testolone)

Provides significant muscle-building effects with fewer systemic side effects compared to traditional steroids.

LGD-4033 (Ligandrol)

Boosts lean muscle mass and strength without the risk of respiratory irritation.

MK-677 (Ibutamoren)

Stimulates growth hormone release, aiding in muscle growth and recovery.

Natural Alternatives

Turkesterone

A plant-based ecdysteroid that supports muscle protein synthesis and recovery.

Ecdysterone

Another natural compound that mimics anabolic effects without the harsh side effects.

Creatine Monohydrate

Enhances strength and muscle mass through improved energy production during workouts.

Other Options

Human Growth Hormone (HGH)

Promotes muscle growth and fat loss, though it requires careful monitoring due to potential side effects.

Testosterone Boosters

Natural supplements like D-Aspartic Acid or Tribulus Terrestris can help optimize testosterone levels for muscle growth.

SARMs Alternatives

Legal and safer versions of SARMs are available, offering similar benefits without the risks associated with traditional SARMs.

Overall

We have explored the phenomenon of "tren cough," a sudden, intense coughing episode often caused by Trenbolone injections due to factors like solvent irritation, prostaglandin release, micro-oil embolism, or histamine activation. Preventive measures such as using salbutamol (via inhaler, oral tablets, or nebulizer), injecting slowly, splitting doses, and opting for lower-concentration solutions were highlighted.

Additionally, alternative compounds to tren cough-inducing steroids were discussed, including peptides like IGF-1 LR3 and TB-500, SARMs such as RAD-140 and LGD-4033, and natural options like Turkesterone, ecdysterone, and creatine. These alternatives provide anabolic effects while minimizing respiratory side effects. The conversation also underscored the importance of proper injection techniques and thoughtful compound selection to reduce risks.

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