Steroids
Thyroid Hormones For Fat Loss In Women
Thyroid hormones play a significant role in regulating metabolism and can impact body weight and fat loss. However, using thyroid hormones for fat loss in women or anyone else should only be done under the guidance and supervision of a qualified healthcare professional. Self-administering thyroid hormones can have serious health risks and is not a safe or effective way to lose weight.
Here are some important things you need to know about thyroid hormones:
Thyroid Function
The thyroid gland produces two primary hormones, thyroxine (T4) and triiodothyronine (T3), which are key in regulating metabolism. When there is an imbalance in these hormones, it can affect metabolism and potentially lead to weight gain or difficulty losing weight.
Hypothyroidism
Hypothyroidism is when the thyroid gland produces insufficient thyroid hormones. Symptoms can include weight gain, fatigue, and difficulty losing weight. In such cases, healthcare professionals may prescribe synthetic thyroid hormone replacement therapy, such as levothyroxine, to restore normal thyroid function.
Hyperthyroidism
Hyperthyroidism is when the thyroid gland produces an excess of thyroid hormones. This can lead to weight loss, increased metabolism, and other symptoms. Identifying and treating the underlying cause of hyperthyroidism is essential, as simply using thyroid hormones for weight loss can be dangerous.
Risks of Self-Medication
Self-administering thyroid hormones can be dangerous in treating hypothyroidism or for weight loss purposes. It can lead to serious health complications, including heart problems, bone loss, and other adverse effects.
Individual Variation
People's responses to thyroid hormones can vary widely. What works for one person may not work for another, and improper use can lead to health problems.
Healthy Lifestyle
A balanced diet and regular exercise is the most effective and safe way to lose fat and maintain a healthy weight. A healthcare professional can guide a personalized weight loss plan.
Consult a Healthcare Professional
If you suspect you have a thyroid disorder or are struggling with weight issues, it's essential to consult a healthcare professional for proper evaluation and guidance. They can diagnose any thyroid conditions and recommend appropriate treatments if necessary.
Real Life Scenario
A 40-year-old woman claimed to be active in the sport. She started to join swimming competitions when she was a kid and eats healthily on organic foods. She, however, admitted her big appetite for eating after training is helpless. Also, she never really counts calories, but fortunately, with the sports she does, she never has an issue with weight or body fat. As years pass, she can’t keep off the fat and took T4 wrongly. The overdose of T4 has led her to bulk. The heart rate began to increase, but the fat loss program was effective, although it caused more trouble.
Then she tried T3, but this time, with a proper 100 mcg/day dosage. However, another problem occurred as the heart rate affected her training, and the fat loss program was no longer effective. She supported her training with fat loss supplements, including thyroid hormone.
But another question comes to mind: is it effective? And what about the difference between T3 and T4?
This woman’s case is a genetically gifted one. She can stay slim while having a big appetite. Not everyone can maintain a lean body while eating a lot and rely only
on training. At the age of 40, the case is different. Our body will experience a certain degradation, and getting back a lean body might not be easy, like when you are 20. Hence, calories are the things to avoid if you want to lose fat.
Fat Loss Supplements:
Fat loss supplements may be effective for some people. It reduces your appetite released by the chemical substance in the supplement. In return, it raises the metabolic rate and the process. This significant loss of appetite causes an individual to eat less – and lose fat. The supplement products generally work like this.
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The T3 Effect
When you take T3, your food must ‘work’ to match the calorie-burning rate. This way, you don’t lose fat.
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The T4 Effect
T4 is rather extreme or stronger than T3. And you will have fat loss.
Thyroid Hormones: Don’t Overdose it
It is important to note that thyroid hormones must not be abused. Once you overdose, it is hard to recover. The powder is not recommended; however, if an individual needs to take it, it must be in a very small dose and prescribed by a nutritionist if possible because there must be an exact 100% certainty.
Some women have been reportedly gaining weight, which is a noticeable sign that they have overdosed on the thyroid. Even when they have struggled, they can’t figure out why. The wrong dosage causes thyroid impairment, slowing down your rate.
The Recommended Intake of Thyroid Hormone:
A healthcare professional should determine the dosage of thyroid hormones (T3 and T4) for women looking to lose weight or manage their thyroid condition based on individual needs and medical history. Self-administering thyroid hormones for weight loss without proper medical guidance can be dangerous and unnecessary.
Here are some tips on T3 and T4 and their roles in thyroid function and metabolism:
- T4 (Thyroxine): T4 is the primary hormone produced by the thyroid gland. It is relatively inactive but is converted into the more active T3 in various body tissues, including the liver. T4 medications are commonly prescribed for hypothyroidism (underactive thyroid).
- T3 (Triiodothyronine): T3 is the more biologically active form of thyroid hormone. It plays a crucial role in regulating metabolism and energy production. In some cases, healthcare providers may prescribe T3 medication (liothyronine) in addition to or instead of T4 for certain thyroid conditions.
When it comes to weight management:
- Hypothyroidism: If a woman has been diagnosed with hypothyroidism, she may be prescribed T4 (levothyroxine) medication to restore thyroid hormone levels to normal. The goal of treatment is to alleviate symptoms of hypothyroidism, such as fatigue, weight gain, and cold intolerance, rather than using thyroid medication solely for weight loss.
- Weight Loss and Thyroid Medication: Using thyroid hormones, whether T3 or T4, as a weight loss tool, is not recommended and can be dangerous. Inappropriate use of thyroid hormones can lead to hyperthyroidism, which can have serious health consequences, including heart problems and bone loss.
It's important to emphasize that thyroid medication should only be prescribed and adjusted by a healthcare provider based on thyroid function tests, medical history, and symptoms. If you suspect you have a thyroid issue or are experiencing difficulty with weight management, consult a healthcare professional for a proper evaluation and treatment plan. They will consider the appropriate T3 and/or T4 dosage based on your specific needs and monitor your progress to ensure safety and effectiveness.
What Are the Appropriate Dosages?
Here are some general guidelines for dosages, but it's essential to follow your healthcare provider's recommendations, as they will determine the appropriate dosage based on your weight needs:
-
Levothyroxine (T4):
- For hypothyroidism: The typical starting dose for adults is 25-50 micrograms (mcg) per day, with adjustments made based on blood tests and symptoms. The goal is to reach a stable TSH (Thyroid-Stimulating Hormone) level within the normal range.
- Maintenance dose: The average maintenance dose for most adults with hypothyroidism ranges from 75 to 150 mcg per day, although it can be higher or lower depending on the individual.
-
Liothyronine (T3):
- T3 is not typically used as a standalone treatment for hypothyroidism but is sometimes prescribed with T4 medications when necessary.
- When used in combination therapy with T4, a common ratio is 1 part T3 to 4 parts T4 (e.g., 5 mcg T3 with 20 mcg T4). The specific dosages should be determined by your healthcare provider based on your condition and response to treatment.
-
Hyperthyroidism:
In cases of hyperthyroidism, the goal is typically to reduce thyroid hormone levels. Your healthcare provider would determine the dosages of antithyroid medications (such as Methimazole or Propylthiouracil) and adjust based on your thyroid hormone levels.
Caution!
It's crucial to take thyroid medications exactly as prescribed and to follow up with your healthcare provider for regular blood tests and monitoring. Thyroid hormone replacement therapy is highly individualized, and the correct dosage can vary widely from person to person.
Additionally, certain factors can affect the absorption of thyroid medications, such as other medications, dietary habits, and gastrointestinal conditions. Therefore, you must inform your healthcare provider about any other medications or supplements you are taking and any changes in your health status.
Never adjust your thyroid medication dosage without consulting your healthcare provider, as improper dosing can lead to adverse effects or inadequate treatment of thyroid disorders. Always seek guidance from a qualified medical professional. In summary:
- The best dosage is less than 50 mcg/day for T3. You need to divide it into 3 doses.
- The best dosage of T4 is less than 200 mcg/day.
T4 vs T3:
T4 has a longer effect when used than T3. Hence, it is preferable to take T4. However, for some individuals, T3 is proven to be more effective. People find that T3 is more convenient in terms of conversion.
Thyroid Affects Most Women:
There are many reasons why women have thyroid issues, and here are some of the factors
- Pregnancy
- PMS
- And per menopause
The calorie intake must be well monitored. The dose of thyroid hormone needs to be a certain number allowed because it will affect the metabolic rate.
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Overall
In summary, thyroid hormones are essential for regulating metabolism. They can influence body weight, but using them for fat loss should only be done under medical supervision when diagnosed with a thyroid disorder. Self-medication or misuse of thyroid hormones for weight loss is unsafe and not recommended. A holistic approach to weight management, including diet and exercise, should be the first defense in achieving and maintaining a healthy weight.
Bodybuilding
Is Training/Lifting Barefoot A Good Idea? Find Out
For decades, the gym floor has echoed with the thud of cushioned sneakers, lifting shoes, and high‑tech trainers promising better stability, more power, and improved performance. Yet in recent years, a surprising shift has taken hold among serious lifters: many are kicking off their footwear entirely. What began as a fringe practice—often dismissed as quirky or unsafe—has evolved into a growing movement embraced by bodybuilders, powerlifters, and functional fitness athletes who swear that training barefoot unlocks a deeper, more natural kind of strength.
At first glance, the idea seems almost counterintuitive. After all, modern athletic shoes are engineered with layers of support, padding, and structure. But that’s exactly the point. As lifters push for better technique, stronger lifts, and more efficient movement patterns, many are realizing that all that cushioning may be doing more harm than good. By removing the barrier between foot and floor, barefoot training forces the body to engage stabilizing muscles that shoes often mute. The result? A stronger foundation, improved balance, and a more connected kinetic chain from the ground up.
Beyond performance, the barefoot trend taps into a broader shift toward natural movement and functional strength. Lifters are rediscovering the importance of foot mechanics—how the toes grip, how the arches support, and how the ankles align. These subtle details influence everything from squat depth to deadlift power. And as more athletes experiment with barefoot sessions, they’re finding that the benefits extend far beyond the feet themselves.
Of course, going shoeless in the gym isn’t just about following a trend. It’s about rethinking how we build strength, questioning long‑held assumptions, and exploring what happens when we strip training back to its most primal form. Serious lifters aren’t throwing away their shoes for style—they’re doing it for results.
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Advantages of Training Barefoot for Pro Bodybuilders
For professional bodybuilders, every detail matters—how the body moves, how muscles fire, and how efficiently force transfers through the kinetic chain. Training barefoot has emerged as a surprisingly effective way to refine these details and unlock performance benefits that shoes often mask.
One of the biggest advantages is enhanced stability. Without the interference of thick soles or elevated heels, the feet can spread naturally, creating a wider, more grounded base. This stability is crucial during heavy compound lifts like squats, deadlifts, and lunges, where even minor wobbling can compromise form or reduce power output. Barefoot training allows bodybuilders to feel the floor directly, improving balance and control under load.
Another major benefit is greater activation of stabilizing muscles, especially in the feet, ankles, and lower legs. Modern footwear often restricts natural movement, causing these smaller muscles to weaken over time. Training barefoot forces them to engage, strengthening the foundation that supports every lift. For bodybuilders, this translates to better joint integrity, improved symmetry, and reduced risk of chronic overuse injuries.
Barefoot lifting also enhances proprioception—the body’s ability to sense position and movement. With more sensory feedback from the ground, athletes can fine‑tune their technique, adjust their stance, and maintain optimal alignment throughout each rep. This heightened awareness can improve squat depth, deadlift mechanics, and overall lifting efficiency.
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Additionally, training without shoes encourages more natural biomechanics. The feet move freely, the arches function as intended, and the ankles maintain a neutral position. This can help correct imbalances caused by years of training in restrictive footwear, ultimately supporting better long‑term performance.
For pro bodybuilders chasing marginal gains, barefoot training offers a simple yet powerful way to build strength from the ground up—literally. It’s not just a trend; it’s a strategic tool for maximizing muscle engagement, improving technique, and enhancing overall athletic longevity.
Possible Downsides of Lifting Barefoot
While barefoot training has gained popularity among casual lifters for its “natural” feel and improved ground contact, the situation is very different for professional bodybuilders. At elite levels, athletes handle extreme loads that demand maximum stability, protection, and performance efficiency. Without proper footwear, the risks multiply — from injuries and reduced leverage to hygiene concerns and long-term joint stress. The following points highlight why barefoot lifting can be problematic for pro bodybuilders.
1. Reduced Foot Protection
Bare feet leave you vulnerable to dropped weights, sharp objects, or heavy equipment. For pro bodybuilders handling massive loads, this risk is amplified.
2. Higher Risk of Injury
Without shoes, the bones, tendons, and ligaments in your feet absorb more stress. Heavy squats or deadlifts can easily cause sprains or fractures.
3. Lack of Arch Support
Shoes provide structural support that helps prevent issues like flat feet or plantar fasciitis. Barefoot lifting removes that safeguard.
4. Instability Under Heavy Loads
Gym floors can be slippery or uneven. Shoes add grip and stability, while barefoot training increases the chance of wobbling or losing balance.
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5. Reduced Performance in Certain Lifts
Olympic lifts and squats often benefit from raised heels or firm soles. Barefoot training limits leverage and can reduce maximum output.
6. Increased Stress on Ankles and Knees
Without cushioning, impact forces travel directly into the joints. Over time, this can contribute to chronic pain or injury.
7. Hygiene Concerns
Gyms are breeding grounds for bacteria and fungi. Training barefoot raises the risk of infections like athlete’s foot.
8. Limited Leg Drive in Deadlifts
While barefoot deadlifting improves ground contact, it reduces leverage compared to specialized lifting shoes designed for maximum force transfer.
9. Not Competition-Ready
Most bodybuilding and powerlifting competitions require footwear. Barefoot training doesn’t translate well to actual performance standards.
10. Potential Long-Term Damage
Repeated barefoot lifting under heavy loads can cause chronic foot problems, misalignment, and reduced career longevity.
Overall
As we mentioned earlier, training barefoot has become a trend among some athletes, but for professional bodybuilders the practice carries both potential benefits and serious drawbacks. On the positive side, lifting without shoes can improve proprioception — the body’s awareness of movement and position — which may enhance balance and stability during certain exercises. Barefoot training also strengthens the small muscles of the feet and ankles, potentially reducing reliance on supportive footwear. For lifts like deadlifts, direct contact with the floor can improve force transfer and reduce unnecessary elevation caused by cushioned soles.
However, the disadvantages are far more significant at elite levels. Bare feet lack protection against dropped weights or sharp equipment, exposing bodybuilders to severe injury risks. Without arch support or cushioning, stress is shifted to the ankles, knees, and hips, increasing the likelihood of chronic pain or joint damage. Performance in squats and Olympic lifts often suffers, since specialized shoes provide leverage and stability that barefoot training cannot replicate. Hygiene is another concern, as gym floors harbor bacteria and fungi. Finally, barefoot lifting does not align with competition standards, where footwear is mandatory.
In short, while barefoot training offers some functional benefits, professional bodybuilders face greater risks that outweigh its advantages.
Anabolic Steroids
Using Insulin Needles to Inject AAS: Pros and Cons
Bodybuilding has long been associated with the pursuit of physical excellence, where athletes and enthusiasts dedicate themselves to sculpting muscular physiques. You need rigorous training, disciplined nutrition, and, in some cases, the use of performance-enhancing substances. Among these substances, anabolic-androgenic steroids (AAS) occupy a controversial space. While medically prescribed for specific conditions, AAS are often used to accelerate muscle growth, improve recovery, and enhance overall performance. Their use, however, is fraught with ethical, legal, and health-related concerns.
One practical issue that arises in this context is the method of administration. AAS are typically injected intramuscularly, requiring needles that can deliver oil-based solutions deep into muscle tissue. Yet, some individuals turn to insulin needles—originally designed for subcutaneous delivery of insulin—as an alternative. This choice is often motivated by the perception that insulin needles are less intimidating, less painful, and more discreet. For bodybuilders who may be inexperienced with injections, the appeal of a smaller, finer needle can be strong.
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However, the suitability of insulin needles for AAS administration is highly debated. While they may offer certain conveniences, their limitations in terms of depth, absorption, and compatibility with thicker solutions raise significant concerns. Misuse can lead to complications ranging from ineffective dosing to infections and tissue damage.
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In bodybuilding culture, where experimentation and peer influence often shape practices, understanding the pros and cons of using insulin needles for AAS injections is essential. By examining both benefits and the potential risks, we can better appreciate the complexities of AAS injection and emphasize the importance of informed, responsible decision-making.
Why Insulin Needles
Insulin needles are generally preferred for many types of injections because they are shorter, thinner, less painful, and reduce the risk of complications compared to larger needles
Patient comfort: Insulin needles are designed to minimize pain. Their fine gauge and short length make injections less intimidating and more tolerable, especially for people who need frequent injections.
Reduced risk of complications: Shorter needles lower the chance of hitting muscle or nerves when delivering medication subcutaneously. This reduces risks like bruising, bleeding, or accidental intramuscular injection
Effective delivery: For insulin and other subcutaneous medications, shorter needles are just as effective as longer ones. They ensure the drug reaches the correct tissue layer without unnecessary depth.
Ease of use: Their design makes them simple to handle, even for patients self-administering injections daily. This accessibility encourages adherence to treatment
Compatibility with subcutaneous injections: Many medications besides insulin—such as certain vaccines, hormones, and biologics—are delivered under the skin. Insulin needles are well-suited for these because they match the required depth and absorption rate.
Insulin Needles vs. Intramuscular Needles in Bodybuilding
When it comes to injecting anabolic-androgenic steroids (AAS), bodybuilders often weigh the choice between insulin needles and traditional intramuscular needles. Insulin needles are very fine and short, usually ranging from 29 to 31 gauge and only a few millimeters in length. This makes them far less intimidating and significantly less painful to use. For athletes who inject frequently, the reduced discomfort and minimal scarring are appealing, especially since visible bruising or scar tissue can detract from the aesthetic goals of bodybuilding. Their wide availability in pharmacies and association with legitimate medical use also adds to their convenience and discretion.
However, insulin needles are designed for subcutaneous injections, meaning they deposit medication just under the skin. AAS, on the other hand, are typically oil-based compounds that require intramuscular delivery for proper absorption. The fine bore of insulin needles makes drawing and injecting these thicker solutions difficult, and their short length often fails to reach muscle tissue. This mismatch can lead to poor absorption, underdosing, or even localized complications such as abscesses and tissue irritation.
Intramuscular needles, by contrast, are longer and thicker—usually 21 to 25 gauge and 25 to 40 millimeters in length. While they cause more pain and can be intimidating for beginners, they are specifically designed to deliver oil-based substances deep into muscle tissue. This ensures that AAS are absorbed effectively and reduces the risk of complications when used correctly. Over time, repeated intramuscular injections may cause bruising or scar tissue, but medically they remain the appropriate tool for this type of administration.
In short, you may prefer insulin needles for their comfort, accessibility, and cosmetic advantages, but intramuscular needles remain the medically suitable option for AAS injections. The perceived safety of insulin needles does not outweigh the risks of improper delivery, making the choice more about convenience than effectiveness.
Downsides of Using Insulin Needles for AAS in Bodybuilding
For bodybuilders, the downsides of insulin needles in AAS use are significant: poor absorption, infection risk, tissue damage, and wasted product. While they may reduce pain and appear more convenient, they compromise both safety and effectiveness. In bodybuilding culture, where results are paramount, these drawbacks make insulin needles a risky and counterproductive choice.
Improper absorption
Insulin needles are designed for subcutaneous injections, but AAS typically require intramuscular delivery. Injecting into fat or shallow tissue can lead to poor absorption, reduced effectiveness, and unpredictable results.
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Viscosity mismatch
AAS solutions are often oil-based and much thicker than insulin. Fine-gauge insulin needles struggle to draw and push these solutions, leading to blocked syringes, incomplete injections, or excessive force that damages tissue.
Risk of infection and abscesses
Because oil may pool in subcutaneous tissue instead of dispersing into muscle, it can irritate the area and create a breeding ground for bacteria. This raises the risk of painful abscesses that may require medical intervention.
Underdosing and wasted product
If the steroid doesn’t reach the muscle, the bodybuilder may not achieve the intended anabolic effect. This not only wastes expensive compounds but also tempts users to increase frequency or dosage, compounding health risks.
Tissue damage
Repeated shallow injections can cause lumps, irritation, or necrosis in fatty tissue. For bodybuilders focused on aesthetics, visible damage under the skin undermines their goals.
False sense of safety
Many athletes assume insulin needles are “safer” because they are smaller and widely used in diabetes care. In reality, this perception can mask the fact that they are medically inappropriate for AAS, leading to dangerous practices.
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Overall
Bodybuilders and athletes often face difficult choices when it comes to performance enhancement, and the method of administering anabolic-androgenic steroids (AAS) is one of them. Insulin needles, with their fine gauge and short length, are attractive because they reduce pain, minimize scarring, and are easy to obtain. For individuals who inject frequently, these qualities can seem like practical advantages.
However, the reality is that insulin needles are not designed for oil-based compounds that require intramuscular delivery. Their short length and narrow bore make them unsuitable for reaching muscle tissue, leading to poor absorption, underdosing, and potential tissue irritation. The risk of infection or abscess formation is also heightened when AAS are deposited into fatty tissue rather than muscle. What may appear to be a safer, more comfortable option can ultimately compromise both health and performance outcomes.
Athletes who prioritize long-term progress must recognize that convenience should never outweigh safety. While insulin needles may seem appealing, they are not always appropriate for AAS administration. The discipline that defines bodybuilding and athletic success should extend to responsible decision-making, ensuring that choices made in pursuit of strength and aesthetics do not undermine overall well-being.
Anabolic Steroids
Is NAD+ The Best Anti-aging Molecule for Men Over 40?
NAD+(Nicotinamide Adenine Dinucleotide) has become the quiet obsession of athletes and bodybuilders who care as much about longevity as they do about performance. For men over 40, the game changes: recovery slows, energy dips, and the margin for error—sleep, nutrition, stress—gets razor-thin. That’s where NAD+ steps in. As a central coenzyme in cellular metabolism, NAD+ powers the mitochondria that generate ATP, supports DNA repair, and helps regulate inflammation and oxidative stress—the exact pressures that compound with age and intense training. The catch? NAD+ levels decline as we get older, and that drop doesn’t just feel like “getting tired”; it shows up as reduced work capacity, stubborn recovery, and a harder fight to preserve lean mass.
For the seasoned lifter, anti-aging isn’t about turning back the clock—it’s about staying dangerous: maintaining strength, clarity, and resilience year after year. By supporting NAD+—through smart training, lifestyle, and targeted precursors like NR or NMN—you’re not chasing a miracle; you’re reinforcing the cellular systems that keep you strong. Think steadier energy across sets, cleaner recovery between sessions, and a more robust response to stressors that typically erode performance after 40.
This article explores how NAD+ intersects with muscle metabolism, hormonal signaling, and recovery pathways, and what practical steps can help you sustain the physique and output you’ve built. If you’re a man over 40 who refuses to age passively, NAD+ isn’t hype—it’s a lever worth understanding and pulling with intention.
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Why NAD+ Levels Drop in Men Over 40
NAD+ levels decline with age because the body’s ability to produce and preserve this vital coenzyme weakens, while demand for it increases.
Reduced biosynthesis: The enzymes and pathways that create NAD+ from precursors like niacin and tryptophan become less efficient over time.
Increased consumption: NAD+ is used by repair enzymes such as PARPs (for DNA repair) and sirtuins (for regulating metabolism and aging). As DNA damage and oxidative stress accumulate with age, these enzymes consume more NAD+, depleting reserves.
Greater degradation: Another enzyme, CD38, becomes more active with age. CD38 breaks down NAD+, and its rising activity is strongly linked to age-related decline in NAD+.
Mitochondrial dysfunction: Aging cells often suffer from less efficient mitochondria. Since NAD+ is central to mitochondrial energy production, dysfunction accelerates its depletion.
Lifestyle and stress factors: Poor sleep, chronic stress, alcohol, and high-intensity training without proper recovery can further drain NAD+ levels, especially in men over 40
Why This Matters for Men Over 40
- Lower NAD+ means slower recovery, reduced energy output, and greater susceptibility to inflammation.
- Declining NAD+ is linked to fatigue, cognitive decline, and accelerated aging.
For athletes and bodybuilders, this translates into harder muscle maintenance, longer recovery windows, and plateaus in performance.
Remedies to Boost NDA+ Levels in Men Over 40
Men and athletes over 40 can boost NAD+ levels through a mix of lifestyle strategies (exercise, fasting, sleep), dietary choices (niacin-rich foods), and supplementation (NR, NMN, NAD+ IV therapy).
Lifestyle Approaches
Regular exercise: Endurance and resistance training stimulate mitochondrial function and naturally increase NAD+.
Intermittent fasting: Periods of caloric restriction activate sirtuins, which depend on NAD+.
Quality sleep: Restorative sleep reduces oxidative stress and preserves NAD+ reserves.
Stress management: Chronic stress elevates NAD+ consumption; mindfulness and recovery practices help conserve it.
Avoid excess alcohol: Alcohol metabolism depletes NAD+, so moderation is key.
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Dietary Strategies
Niacin-rich foods: Chicken, tuna, salmon, turkey, and mushrooms provide vitamin B3, a precursor to NAD+.
Tryptophan sources: Eggs, dairy, and nuts support NAD+ synthesis via the kynurenine pathway.
Polyphenols: Resveratrol (found in grapes and red wine) activates sirtuins, indirectly supporting NAD+.
Ketogenic diet: Promotes fat metabolism and enhances NAD+/NADH ratio.
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Supplementation
Nicotinamide Riboside (NR): A direct precursor shown to raise NAD+ levels in humans.
Nicotinamide Mononucleotide (NMN): Another precursor with strong evidence for boosting NAD+ and supporting anti-aging pathways.
NAD+ IV therapy: Direct infusion used by some athletes for rapid replenishment.
Co-factors like magnesium and B vitamins: Support enzymatic reactions that sustain NAD+ metabolism.
Advanced/Medical Options
CD38 inhibitors: Experimental compounds that reduce NAD+ breakdown.
PARP inhibitors: Limit excessive NAD+ consumption during DNA repair (still under research).
Hormonal optimization: Testosterone and growth hormone balance indirectly support NAD+ pathways in men over 40.
The Catch:
Energy & endurance: Higher NAD+ means more efficient ATP production.
Recovery & repair: Supports DNA repair and reduces inflammation after training.
Anti-aging resilience: Helps maintain muscle mass, cognitive clarity, and metabolic health.
NAD+ Delivery Methods
1. Intravenous (IV) NAD+ Therapy
- Direct infusion of NAD+ into the bloodstream.
- Used in clinics for rapid replenishment of cellular NAD+.
- Often promoted for anti-aging, recovery, and cognitive clarity.
- Sessions can last several hours, as NAD+ must be infused slowly to avoid side effects (like nausea or flushing).
Dosing: Typically ranges from 250 mg to 1000 mg per session, but exact protocols vary by clinic and medical supervision.
2. Intramuscular or Subcutaneous Injections
- Less common than IV, but some practitioners use NAD+ injections for quicker delivery than oral supplements.
- Provides a shorter, more concentrated boost compared to IV drip.
- Still requires medical oversight, as NAD+ injections can be uncomfortable and must be dosed carefully.
Oral Supplementation
1. NAD+ Precursors (NMN & NR)
- Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR) are widely available as capsules or powders.
- These compounds are converted into NAD+ inside cells.
- Easier, safer, and more practical for long-term use compared to IV therapy.
Dosing: Common ranges are 250–500 mg daily, though some studies explore higher doses.
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2. NAD+ Capsules
- Direct oral NAD+ supplements exist, but absorption is less efficient than precursors.
- Most experts recommend NMN or NR instead, as they are better studied and more bioavailable.
Overall
In the pursuit of strength, endurance, and longevity, NAD+ emerges as more than just a biochemical cofactor—it is a cornerstone of vitality for athletes and men over 40. As natural levels decline with age, the consequences ripple through energy, recovery, and resilience. By embracing lifestyle strategies, nutrient-rich diets, and modern supplementation, bodybuilders can sustain performance while slowing the clock on cellular aging. Whether through daily NMN or NR, or targeted therapies under medical guidance, supporting NAD+ is an investment in both present power and future health—a path to staying strong, sharp, and ageless in the decades ahead.
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