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Arachidonic Acid


Arachidonic Acid

Arachidonic acid, a part of the Omega-6 group,  is an essential acid. Typically, stored in the cell membranes and is the first to send out the signal that a repair is needed for the body’s damage muscles. And thanks to William Llewellyn, who is a performance-enhancing scientist, who took the time to study and developed arachidonic acid supplementation protocols that are being used for an enhanced muscle growth. Now you have a question that Is Arachidonic acid a steroid? Well, It is not a steroid as we tell you that it a part of the Omega-6 group.

Arachidonic Acid Benefitsarachid

  • Considered as the main component in creating dienolic prostaglandins such as PGE2 and PGF2, the Arachidonic acid helps in the production of protein synthesis and muscle hypertrophy.  These two processes occur right after doing strenuous activities such as exercise.
  • Arachidonic acid is also responsible with amplified IGF-1 (Insulin-Like Growth Factor) signaling, which enhances satellite cell proliferation and activation.  This also increases the regeneration rate of one's muscle cells, androgen receptor synthesis, as well as increasing Nitric Oxide formation.
  • Arachidonic acid also provides improvements of vascularity, that can be obtained through the stimulation of angiogenesis (blood vessel regeneration) in the muscles in your body that are trained. It also enhances body composition by subdividing negative nutrients inhibition of stearoyl-CoA desaturase-1.
  • Arachidonic acid also inhibits resistin.


  • Amateur and professional athletes, individuals who are into weight training may greatly benefit with arachidonic acid supplement.  It is a known fact that as one shift into high gear, arachidonic acid levels in the body normally decreases which in turn affect the production of anabolic prostaglandins.

Read More: The Role of PGF2a in Muscle Growth

  • Arachidonic acid is commonly used by bodybuilders, regular gym attendees, active individuals who play physical sports on a daily basis or participants of activities that require rapid bursts of performance.  Athletes that experience reduced level of arachidonic acid will notice a decline with the muscle’s ability to stimulate muscle growth, also known as training stagnation.


As a common practice, long-term usage typically consumes 75mg to 250mg per day and between 500mg and a 1000mg daily for a rapid, short-term effect.  It still depends on the individuals purpose for taking in arachidonic acid.

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Effects To The Body

Individuals who are taking in arachidonic acid may experience:

  • Insomnia
  • Headaches
  • Soreness of the muscles and joints

However, the majority of arachidonic acid takers does not experience any side effects.

Arachidonic acid is not advisable for individuals that are not actively participating in physical activities, as well as pregnant females.  It is also not advisable for individuals with a variety of disease and conditions, such as:

  • High blood pressure
  • Asthma
  • Prostate enlargement
  • High cholesterol
  • Irritable bowel syndrome
  • Cancer
  • Heart disease
  • Diabetes
  • Any inflammatory disease

Mechanism Of Work

Mechanism of Work

Arachidonic Acid (AA or ARA) is a polyunsaturated omega-6 fatty acid commonly found in the dietary animal such as meat, eggs, dairy or by biosynthesis from linoleic acid.

Arachidonic acid plays an unprecedented role in repair and growth of skeletal muscle tissue, thus making arachidonic acid a very significant dietary component in muscle growth and development process.

Nutritional supplements that promote the boost in strength, more muscle mass, and improved performance during training will most probably contain arachidonic acid.

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Arachidonic Acid and Bodybuilding

Arachidonic Acid and Bodybuilding

An increase in strenuous activities has shown that it consumed the omega-6 fatty acid levels found in the skeletal muscles. Bodybuilders who use arachidonic acid as part of their supplement can greatly benefit them.  Arachidonic acid is not considered as a fatty acid, it becomes one if linoleic acid is deficient.

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Arachidonic Acid And Exercise

Arachidonic Acid and Exercise

In a study performed to 31 resistance-trained males in a randomized and double-blind manner, either with arachidonic acid (1 gram per day, n = 15) or a placebo (1 gram of corn oil per day, n = 16), that was doing a 4-day per week training for 50 days.  Positive results were obtained from the group that intakes arachidonic acid (0.3 ± 1.2 W·kg-1).

A relative increase in peak power is recorded at 7.1% and average power at 3.6% after the 50-day training period compared to the placebo group (0.2 ± 0.7 W·kg-1).   However, arachidonic acid did not directly impact muscle mass or weight lifting measures of power (bench press and leg press).

The study shows an inconclusive preliminary evidence that best arachidonic acid supplements can enhance resistance training. This study was funded by Molecular Nutrition (arachidonic acid manufacturer and patent holder).

In another study conducted to thirty recreationally trained males that participated in an 8-week, 3-day per week, resistance-training program, arachidonic acid takes showed a greater lean body mass gains and skeletal muscle thickness compared to the placebo group. The total power and strength are also greater than the placebo group.

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With the conclusion of the clinical study, total testosterone level and cortisol concentrations were both unchanged after the 50-day study period.

Arachidonic Acid And Inflammation

Inflammation is the body’s immune system way of fighting off infection and injury.  Eccentric and concentric muscle training can also result in acute inflammation. Some disorders can also result in inflammation such as arthritis, allergies, asthma, obesity, atherosclerosis, and others. In theory, localized inflammatory may have the anabolic effect.

Read More: Does Proviron Improve The Anabolic Effect Of Steroids?

Arachidonic acid, when oxygenated, transforms into a variety of products, and some facilitate inflammatory reactions. Arachidonic acid is known to stimulate the production of pro-inflammatory prostaglandins and leukotrienes through in the COX (cyclooxygenase), LOX (lipoxygenase) and cytochrome P450 enzyme conversion process.

However, studies are showing mixed results. It is being argued that the intake of omega-6 polyunsaturated fatty acids may lead to a conflict between omega-6 and omega-3 metabolism that can result in a lesser production of anti-inflammatory from omega-3.  On the test conducted on the human subjects, high intakes of omega-6 created no association with the inflammatory markers elevated level.

 However, consumption of arachidonic acid is known to aggravate symptoms of joint pains or active inflammatory disease, because it is presumed that the acid is being converted to inflammatory compounds.  It is therefore suggested that individuals who have inflammatory disease do not consume high levels of arachidonic acid.

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