Steroids

Covid-19: Advices to Steroid Users

Published

4 years ago

December 10, 2020

Paul

If you think visiting the gym during the Covid period is a breeze, think again. Not now, not before a lasting solution for the virus is found. Covid-19 continues to wreak havoc worldwide. People no longer have the luxury of working out in groups or visiting public gyms. Like everyone else, Steroid users are not sure of the relationship between the virus and the drugs they take. Luckily for people already using steroids, you may have found a solution. Instead, your body may be able to fight the virus thanks to particular strains of corticosteroids. Medical experts are leaving no stone unturned in their quest to find solutions for Covid-19. That means exploring a range of treatment options, including possible treatment with systemic corticosteroids.

Steroids help people treat a range of conditions, specifically to manage pain and inflammation. However, most of the steroids used today are for bodybuilding, fitness, and performance enhancement.

Corticosteroids and Covid-19 Management: Dexamethasone

The World Health Organization has researched several types of steroids' effectiveness in managing Covid-19. The findings are inconclusive, but there is hope that steroids could help manage the virus better than traditional medicine. The most significant advantage of using corticosteroids for Covid treatment is that they have fewer side effects than regular clinical medication.

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In a July 17, 2020 research, the WHO evaluated corticosteroids versus ordinary Covid care for patients. Mortality data was made available by subgroup, i.e., severe and non-severe Covid cases. The drug was administered to both groups of patients, and we can say that the future is bright for steroids as a possible treatment option for Covid-19. One particular steroid caught the medical world's attention in this regard – Dexamethasone.

Dexamethasone

A popular steroid used to manage arthritis funds to help save the lives of critically ill people with the virus. Preliminary findings show that Dexamethasone could save ICU patients' lives by a third and those under oxygen only by a fifth. Dexamethasone is usually used to reduce pain and inflammation caused by autoimmune conditions and has been on the WHO's watch list to treat various conditions since the 1960s. However, patients not critically ill with the virus didn't receive significant benefits from using the drug.

The best thing about Dexamethasone in Covid treatment is that you don't have to sweat to find it. It is both accessible and affordable to people who would otherwise not access regular Covid-19 medication. Also, use Dexamethasone alongside other Covid-19 treatment options without exposing the patient to adverse reactions.

Although Dexamethasone is now widely used for this purpose, the WHO has not yet released final findings alongside clinical guidance on drug use. Once this is one, we will better understand this revolutionary intervention in managing the virus.

Related Article:: Steroid Acne in Men: Causes, Treatment, and Prevention

What Are Bodybuilders Afraid of?

Besides the fear of the virus, bodybuilders and fitness professionals are afraid of many other things related to Covid-19. Believe it or not, bodybuilders are now suffering from panic attacks caused by a virus that is billions of times smaller than them. And they are justified to fear it. It is difficult to fight an invisible enemy, which shifts the battleground to unfamiliar territory. Yes, unfamiliar territory, despite it being your own body. Here are a few things about the virus causing sleepless nights for bodybuilders.

Long-Term Effects

Covid-19 is feared not because it has a high mortality rate. It can be considered less dangerous than more than a dozen other diseases. What makes this particular virus dreadful is how it attacks the body. It comes in intensive waves that overwhelm people with relatively weak immune systems. Additionally, the virus has long-term effects that could accompany someone for a long. There have been reports that the virus leaves one's lungs working below the average capacity even after recovery.

That is particularly scary for people interested in fitness and bodybuilding because their lungs are the engine that drives them. For one to withstand long intensive workouts, their lungs must function exceptionally well. Covid threatens to take away this fundamental aspect of your hobby or career. It is probably why bodybuilders are more afraid of the disease than the rest of the population.

Must Read: 5 Fitness Tips While Gyms Are Closed

The High Probability of Catching It Outdoors

Bodybuilding and fitness is some contact sport involving working close to people. Additionally, there are many items, equipment, and surfaces bodybuilders share. That makes it risky to continue your routine as a bodybuilder or fitness person.

However, bodybuilders don't have a choice about where to work out in the current situation. Once you are locked in or your movement is restricted, the chances are that you may not end up visiting your usual workout spots. It may seem uncomfortable, but it is for the best. There is no point in catching the virus when you can transform your house and backyard into a gym. It may not be a world-class gym, but it will serve its purpose for the time being.

The Challenges of Working Indoors

For bodybuilders who are not used to working out at home, this period is most challenging for their lives and careers. Before the virus came, every bodybuilder had a plan and expectations tied to it. For most of them, working in groups or pairs achieves double the results compared to working independently. Everybody is now locked in their house to try and maintain normalcy in an abnormal world. It may take longer to adjust to the new normal, but there are a few options.

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Several bodybuilders have reported being unable to maintain bulk while working at home. Twin bodybuilder brothers Brian and Daniel Zhou have indicated that home workouts do not help them achieve the desired results in maintaining bulk. Sticking to their routine has been particularly difficult, partly because every other piece of equipment they use is now not within their reach. Daniel went as far as buying a pull-up bar to help him with back exercises. Still, that didn't seem to help him achieve the desired results. So he had to fill his backpack with water bottles to try and make it more intensive. The twins have been coming up with innovations here and there to ensure they are not disrespecting their routines.

Related Article:: 5 Home Gym Essentials To Build A Great Body

Every bodybuilder out there is going through a challenge that comes with deviating from their routine. Although some have successfully returned to their careers on track, many are still struggling to stay afloat. Some of them will have lost form and focus in the long run, which is a terrifying thought for every bodybuilder and fitness person.

Lack of Competition

Although bodybuilders can monitor their bodybuilding progress and determine if their form is improving, stagnating, or deteriorating, they need competition. Competition helps keep a bodybuilder on their toes regarding training and dieting. Some of them might become complacent and lose form without competition and contests. Most bodybuilders are scared of that happening and are trying their best to compete with themselves until the pandemic is overcome.

The community at the gym does a lot for the bodybuilder. A gym is more than just a place to lift weights. You need people around to boost your morale. Most importantly, it would help if you had more experience than you to point directions for you. That means evoking a gym at home is no small task for any bodybuilder.

Dieting is A Problem

With the pandemic's onset and persistence, most bodybuilders are increasingly finding it difficult to stick to their dieting programs. The Covid crisis has affected virtually every aspect of the economy. Bodybuilders are now finding it hard to get their superfoods and other supplements. The lack of critical bodybuilding stuff threatens a bodybuilder's form.

Must Read:: The Correct Diet Plan That Complements Your Bodybuilding Cycle!

Guidelines for Steroid Use During the Covid Period

While the coronavirus pandemic has affected how one does their bodybuilding and fitness workouts, but not your steroid intake, steroid users are in three groups; those infected, recovering, or uninfected. So, what should you or not do about steroids in either group? We have prepared a few guidelines for you.

Don't stop taking your steroid tablets.

Suppose you happen to contract covid-19. If you are in home-based care, you should let your doctor know you are taking steroids before they start prescribing other drugs. Getting all the information you need about taking steroids alongside regular medication in the hospital is a bit easy. However, remember that this is a relatively new virus that not even medics know much about. Everything ongoing right now concerning treatment is merely experimentation. What we are sure about is that most modern medications have not been entirely successful n managing it. In any case, we often talk about managing the condition rather than managing it. You never know; maybe the steroids you use could be the ultimate Covid-19 treatment.

Covid-19 Complications

Covid-19 is continually causing new complications as the strains of the virus increase. That means you may not know if you are suffering from covid-19. If you develop conditions that warrant you to use steroids, such as joint pains and inflammation, don't be quick to use them. Instead, consult your rheumatology team or doctor first. Get checked by a doctor to know what you are ailing from. In the unfortunate event that you turn out to be Covid-19 positive, the doctor will decide whether you should include corticosteroids in your treatment or not. You can suggest using approved corticosteroids such as Dexamethasone for your treatment, but it will be for them to decide. If your condition is unclear, the doctor can give you a steroid injection as a last resort option. While doing so, they should give you the lowest possible dose to avoid aggravating the condition further.

How to take Steroids during Covid-19?

Always take steroids and other Covid management drugs interchangeably. If you stopped taking steroids more than a month before contracting Covid-19, you don't need to use them now unless your doctor suggests it. You only use them alongside the other drugs provided if you tested positive while still using them or within less than a month of stopping their use. That precaution is essential because you never know which Covid-19 management drugs cause an adverse reaction when combined with steroids. Most importantly, ensure the steroid dosage is always the lowest possible.

Immunosuppressant drugs and steroids

Take plenty of immunosuppressant drugs and steroids l because you may need to reduce your immune system in the face of incurable viral diseases. Suppressing your immune system is the best chance you have against diseases like Covid-19, especially if you're a steroid person. The reason is that the drugs treat and prevent the virus's hyper-inflammatory phase, which usually becomes fatal after a short time. Although these drugs may prove harmful when they reduce your response to the virus, it is still a viable option, given that the virus can even kill hours after contracting it.

Conclusion

Steroids have received negative coverage by the media because of their perceived harmful effects on users. However, scientists have debunked most of the myths associated with steroids. There haven't been any reports about the negative effect of steroids on people suffering from Covid-19. Instead, the drugs have been found to treat viral diseases like the case of Dexamethasone. The only you should be careful about is balancing between corticosteroids and other Covid drugs.

Additionally, you may have to make changes to your steroid intake, like the dosage and frequency of use, to avoid jamming your system with too much of it. Otherwise, you are free to continue using your steroids if you contract the virus, not only to get the usual benefits but also to treat the virus as well possibly. Until the pandemic is contained, be safe and keep practicing. We want to see your best form when you finally come out.

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Steroids

Decoding IGF-1 LR3: A Guide to its Benefits

Published

4 days ago

April 25, 2025

Sane

IGF-1 LR3 (Insulin-like Growth Factor-1 Long Arg3) is a synthetic variant of IGF-1, a hormone produced by the liver in response to growth hormone (GH). Unlike GH, which works indirectly, IGF-1 directly facilitates the growth and repair of muscle cells.

Related Article: Ostarine for Beginners; The Ultimate Guide

This modified version of IGF-1 is engineered to avoid binding with IGF-binding proteins, extending its half-life to 20–30 hours. As a result, it remains active in the body significantly longer than natural IGF-1.

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Many performance athletes incorporate IGF-1 LR3 post-workout to enhance muscle growth, speed up recovery, and support fat loss. When injected into specific muscle groups, it often produces localized effects. Additionally, it helps with nutrient distribution and, in some cases, improves insulin sensitivity.

On the other hand, human growth hormone (HGH) operates more broadly and indirectly, stimulating the liver to produce IGF-1 and offering more systemic benefits such as improved skin health, joint support, and fat reduction, albeit at a slower pace.

Typical IGF-1 LR3 doses range from 20–50 mcg daily, administered subcutaneously or intramuscularly, often following a workout.

Key Features of IGF-1 LR3

Enhanced Bioavailability: It avoids binding with IGF-binding proteins, increasing its potency.

Muscle Growth & Repair: Directly stimulates muscle cell proliferation and differentiation.

Improved Nutrient Distribution: Helps shuttle nutrients into muscle cells, supporting recovery.

Potential Fat Loss Benefits: Some users report improved insulin sensitivity and fat metabolism.

Mechanism of Action

IGF-1 LR3 interacts with IGF-1 receptors on muscle cells, activating pathways like PI3K-AKT and MAPK, which are crucial for cell growth and regeneration. This makes it a powerful tool for bodybuilders and athletes looking to optimize recovery and muscle development.

What Are the Top 10 Alternatives to IGF-1 LR3?

Here are some of the top alternatives to IGF-1 LR3, each with unique benefits for muscle growth, recovery, and performance:

BPC-157 – Known for its regenerative properties, it enhances healing and tissue repair.

CJC-1295 – A growth hormone-releasing peptide that boosts GH levels for muscle development.

Ipamorelin – Stimulates GH release with minimal side effects, making it a safer option.

MK-677 (Ibutamoren) – A potent GH secretagogue that promotes muscle growth and fat loss.

Sermorelin – Encourages natural GH production, supporting recovery and lean muscle gains.

Tesamorelin – Primarily used for fat loss, but also aids in muscle preservation.

Follistatin-344 – Inhibits myostatin, allowing for increased muscle hypertrophy.

PEG-MGF (Pegylated Mechano Growth Factor) – Enhances muscle repair and growth post-exercise.

GHRP-6 – Stimulates appetite and GH release, supporting muscle mass gains.

GHRP-2 – Similar to GHRP-6 but with fewer hunger-related side effects.

Each of these peptides has distinct mechanisms and benefits.

Must Read: Are Nootropics a Better Option to AAS?

Potential Risks Associated With IGF-1 LR3

IGF-1 LR3 comes with several potential risks, especially for bodybuilders using it to enhance muscle growth. Here are some key concerns:

Hypoglycemia (Low Blood Sugar) – IGF-1 LR3 increases glucose uptake in muscle cells, which can lead to dangerously low blood sugar levels if not managed properly.

Organ Growth – Since IGF-1 affects all tissues, excessive use may lead to unwanted growth in organs, increasing health risks.

Cancer Risk – IGF-1 plays a role in cell proliferation, and elevated levels have been linked to an increased risk of certain cancers.

Water Retention & Edema – Some users experience bloating and fluid retention, which can affect performance and aesthetics.

Joint Pain & Stiffness – Excessive IGF-1 levels may contribute to joint discomfort due to increased tissue growth.

Cardiovascular Issues – There is some concern that IGF-1 LR3 could contribute to heart enlargement or other cardiovascular complications.

Desensitization – Long-term use may reduce the body's natural IGF-1 production, leading to dependency

Overall

IGF-1 LR3's ability to bypass IGF-binding proteins makes it more potent but also increases the likelihood of desensitization with prolonged use. For those considering it, careful dosing and monitoring are crucial to mitigate side effects.

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Steroids

AOD-9604: The Fat-Burning Peptide Explained

Published

3 weeks ago

April 9, 2025

Sane

AOD-9604, along with the similar HGH Frag 176-191, is a peptide derived from Growth Hormone that includes only the amino acids in HGH responsible for stimulating fat breakdown, known as lipolysis.

This means that these peptides offer the fat-burning benefits of HGH without its other effects—whether beneficial or adverse—and come at a lower cost.

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Lipolysis refers to the process where fat cells are broken down to be utilized as energy. AOD-9604 promotes accelerated fat loss by increasing the body's use of fat as fuel.

For optimal results, the peptides should be used in a fasted state. AOD-9604 and Frag 176-191 are most effective when administered at a dose of 125-250mcg before bedtime (at least 3-4 hours after eating) and in the morning at the same dose, followed by a fasting period of 3-4 hours, ideally combined with fasted cardio.

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Similar Peptides with Fat-Burning Effect

Here’s a list of 10 peptides similar to AOD-9604, each with a brief description:

Ipamorelin: A growth hormone-releasing peptide (GHRP) that stimulates the natural release of growth hormone, promoting fat loss, muscle growth, and improved recovery without affecting other hormones like cortisol or prolactin.

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CJC-1295: A peptide that increases growth hormone and IGF-1 levels, aiding in fat loss, muscle gain, and improved sleep quality. It has a long half-life, making it convenient for users.

HGH Frag 176-191: A fragment of human growth hormone specifically designed for fat-burning. It targets adipose tissue without the broader effects of full-length HGH.

Tesamorelin: Known for reducing visceral fat, this peptide stimulates the release of growth hormone and is often used for weight management and metabolic health.

BPC-157: While primarily known for healing and recovery, BPC-157 can support fat loss indirectly by improving gut health and reducing inflammation.

Melanotan II: Originally developed for skin tanning, it also has appetite-suppressing properties, making it useful for weight management.

Thymosin Beta-4 (TB-500): Focused on healing and recovery, it can enhance physical performance and indirectly support fat loss through improved activity levels.

GHRP-6: A growth hormone-releasing peptide that boosts appetite and metabolism, aiding in muscle growth and fat loss.

Semaglutide: A GLP-1 receptor agonist that regulates appetite and blood sugar levels, making it effective for weight loss and metabolic health.

MK-677 (Ibutamoren): A growth hormone secretagogue that increases growth hormone and IGF-1 levels, promoting fat loss, muscle gain, and improved recovery.

List of Peptides With a Counteractive Effect Bodybuilders Must Avoid

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Some peptides can inadvertently lead to fat gain due to their effects on metabolism and appetite regulation. Here are a few that bodybuilders might want to avoid or use cautiously:

GHRP-6 – While it stimulates growth hormone release, it also significantly increases appetite, which can lead to excess calorie consumption and fat gain.
IGF-1 LR3 – This peptide enhances muscle growth but can also promote fat storage if not carefully managed with diet and training.
MK-677 (Ibutamoren) – Though technically a growth hormone secretagogue rather than a peptide, it boosts GH levels but often leads to increased hunger and potential fat accumulation.
CJC-1295 with DAC – While effective for muscle growth, its prolonged GH release can sometimes lead to unwanted fat retention if not paired with a strict diet

Overall

AOD-9604, derived from Growth Hormone, stimulates fat-burning by targeting lipolysis—the breakdown of fat for energy. It delivers these benefits without the additional effects of Growth Hormone, making it more cost-effective. For maximum effectiveness, it should be administered in a fasted state, ideally before bed and again in the morning at 125-250mcg doses. Pairing its use with fasting and fasted cardio can further enhance fat loss. Its sole focus is on improving the body’s ability to burn fat efficiently.

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Understanding Trenbolone-Induced Cough (“Tren Cough”)

Published

3 weeks ago

April 7, 2025

Sane

Trenbolone, a potent anabolic steroid, can sometimes cause “tren cough”—a sudden and intense coughing episode shortly after injection. Although not exclusive to Trenbolone, it is more commonly associated with this substance due to its highly irritant nature.

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Mechanisms Behind Tren Cough

Solvent and Carrier Irritation

Trenbolone formulations often include volatile solvents like benzyl alcohol or benzyl benzoate, which may irritate lung tissues when absorbed quickly into systemic circulation.

Prostaglandin Release

Trenbolone promotes increased production of prostaglandins, particularly PGF2α. This compound triggers contraction in the smooth muscles of the lungs, leading to bronchoconstriction and coughing.

Micro-Oil Embolism

Tiny oil droplets from an injection can reach capillaries and travel to the lungs, causing mild embolic reactions that lead to temporary oxygen deprivation and coughing.

Histamine and Mast Cell Activation

For some individuals, Trenbolone triggers histamine release and mast cell activation, mimicking an allergic response and causing bronchospasms and cough reflexes.

Related Article: Best Syringes for Steroid Injection on Amazon

Using Salbutamol (Albuterol) to Manage Tren Cough

Salbutamol, a widely-used β2-adrenergic receptor agonist, can alleviate tren cough symptoms by:
Relaxing bronchial muscles, easing spasms that cause coughing.
Inhibiting prostaglandin effects, reducing bronchoconstriction associated with PGF2α.
Opening airways, preventing severe respiratory restrictions in susceptible individuals.

Application Methods

Inhaler (Optimal)

Take 1–2 puffs of salbutamol (100–200 mcg) 5–10 minutes before a Trenbolone injection. If coughing occurs afterward, additional puffs can swiftly resolve the issue.

Oral Tablets (Moderate)

Consuming 2–4 mg tablets 30–60 minutes before injection offers slower, longer-lasting relief but may be less effective than inhalation methods.

Nebulizer (Severe Cases)

For individuals with frequent episodes, nebulized doses of 2.5 mg salbutamol can provide substantial relief.

Preventive Measures to Reduce Tren Cough Risk

Inject slowly to minimize systemic absorption and irritant effects.
Split doses to lower reaction severity with smaller quantities.
Opt for ventrogluteal injection sites, which have fewer blood vessels, reducing oil embolism risk.
Choose lower-concentration solutions to lessen irritation, as higher concentrations (e.g., Tren Ace 200 mg/ml) are more likely to provoke reactions.

What Other Steroids Can Induce Coughing?

Here's a curated list of peptides, SARMs, and PEDs that may potentially cause coughing or respiratory irritation in bodybuilders and fitness enthusiasts:

Peptides

IGF-1 LR3 (Insulin-like Growth Factor): Known for its anabolic effects, IGF-1 LR3 can occasionally cause mild respiratory irritation due to systemic absorption.

TB-500 (Thymosin Beta-4): While rare, improper injection techniques or high doses may lead to transient coughing episodes.

GHRP-6 (Growth Hormone-Releasing Peptide): This peptide can stimulate histamine release, potentially leading to bronchospasms and coughing.

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SARMs (Selective Androgen Receptor Modulators)

RAD-140: (Testolone) Some users report throat irritation or coughing, often attributed to solvents used in liquid formulations.

YK-11: Known for its myostatin-inhibiting properties, YK-11 may cause mild respiratory discomfort in sensitive individuals.

LGD-4033 (Ligandrol): Though uncommon, some users experience coughing due to carrier solvents or allergic-like reactions.

PEDs (Performance-Enhancing Drugs)

Boldenone Undecylenate (Equipoise): This injectable steroid can cause “Equipoise cough,” similar to tren cough, due to oil embolism or irritant solvents.

Testosterone Suspension: The water-based formulation may lead to coughing episodes if injected improperly or absorbed rapidly.

Nandrolone Decanoate (Deca-Durabolin): While less common, coughing can occur due to histamine release or systemic irritation.

More Tips to Minimize Coughing Risks

Use proper injection techniques to avoid embolic reactions.
Opt for lower-concentration solutions to reduce irritant effects.
Consider antihistamines or bronchodilators for individuals prone to respiratory sensitivity.

Are There Alternatives to Cough-inducing Steroids?

Here are some alternatives to cough-inducing steroids that can provide similar anabolic effects while minimizing respiratory irritation:

Peptides

IGF-1 LR3 (Insulin-like Growth Factor)

Promotes muscle growth and recovery without the irritant properties of certain steroids.

TB-500 (Thymosin Beta-4)

Enhances tissue repair and reduces inflammation, making it a safer option for recovery.

BPC-157 (Body Protection Compound)

Known for its healing properties, it supports muscle repair and joint health.

SARMs (Selective Androgen Receptor Modulators)

RAD-140 (Testolone)

Provides significant muscle-building effects with fewer systemic side effects compared to traditional steroids.

LGD-4033 (Ligandrol)

Boosts lean muscle mass and strength without the risk of respiratory irritation.

MK-677 (Ibutamoren)

Stimulates growth hormone release, aiding in muscle growth and recovery.

Natural Alternatives

Turkesterone

A plant-based ecdysteroid that supports muscle protein synthesis and recovery.

Ecdysterone

Another natural compound that mimics anabolic effects without the harsh side effects.

Creatine Monohydrate

Enhances strength and muscle mass through improved energy production during workouts.

Other Options

Human Growth Hormone (HGH)

Promotes muscle growth and fat loss, though it requires careful monitoring due to potential side effects.

Testosterone Boosters

Natural supplements like D-Aspartic Acid or Tribulus Terrestris can help optimize testosterone levels for muscle growth.

SARMs Alternatives

Legal and safer versions of SARMs are available, offering similar benefits without the risks associated with traditional SARMs.

Overall

We have explored the phenomenon of "tren cough," a sudden, intense coughing episode often caused by Trenbolone injections due to factors like solvent irritation, prostaglandin release, micro-oil embolism, or histamine activation. Preventive measures such as using salbutamol (via inhaler, oral tablets, or nebulizer), injecting slowly, splitting doses, and opting for lower-concentration solutions were highlighted.

Additionally, alternative compounds to tren cough-inducing steroids were discussed, including peptides like IGF-1 LR3 and TB-500, SARMs such as RAD-140 and LGD-4033, and natural options like Turkesterone, ecdysterone, and creatine. These alternatives provide anabolic effects while minimizing respiratory side effects. The conversation also underscored the importance of proper injection techniques and thoughtful compound selection to reduce risks.

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