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Steroids: Frequently Asked Questions

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Taking steroids is very common for experienced bodybuilders and athletes who want to advance their drive and muscle power. But to be able to properly use them you should first know the in’s and outs of steroid use. Steroids are synthetic hormones that can be very safe and are proven to be helpful in gaining muscle mass.

Follow the guide below to answer the most important questions you have before using steroids.

What are The Benefits of Steroids?

What are the Benefits of Steroids?

Steroid use has become fairly mainstream in bodybuilding and intensive exercise routines over the last few decades. Though they’ve sometimes been the brunt of a lot of flack in the media, we’ve learned over the years that they actually have many benefits for athletes.

Read More: Do Bodybuilding Supplements Really Work?

Using steroids have been proven in the medical community to help build muscle and repair muscle tissues more quickly. It gives athletes a greater drive and spikes their workouts with greater endurance and stamina.

What are the Risks of Using Anabolic Steroids?

What are the Risks of Using Anabolic Steroids?

Like everything foreign to the human system there will always be risks involved. Steroids are synthetic hormones designed to affect the body like testosterone because the body closely regulates these hormones sometimes a large spike that’s not closely monitored can do more harm than good.

These risks include shrinking of the testicles, reduced sperm count, severe mood swings or altered behavior like anger sometimes called “roid rage”, swelling of the breast tissues, increased body hair growth, and acne. These risks can be avoided in some cases by only taking steroids in recommended dosages and giving yourself plenty of recovery time during your off-weeks in your steroids cycles.

You should also make sure to consult with your doctor about any unforeseen complications that could come from prescription medications you’re already taking or underlying medical conditions.

Are Steroids Safe For Women?

Are Steroids Safe for Women?

Over the counter, steroids are currently not approved for women. Because women produce testosterone at a much lower rate than men using steroids can drastically affect the female body.

Risks for women include shrinking of the breasts, enlargement of the clitoris, deepening of the voice, body hair growth and male pattern scalp hair loss.

Must Read: Best Anabolic Steroids For Women

Is there an Age Limit?

Is there an Age Limit?

Steroids are not approved for anyone under the age of 21. This is because until 21 you still have a possibility of growth plates being affected. If steroids are used by someone with open growth plates the synthetic hormones can prematurely close them halting any future growth in height, shoulder width, or muscle mass.

Healthy individuals under the age of 21 have no reason to worry about needing extra hormones because they will have plenty of natural testosterone in their systems anyway.

Must Read: How Body Builder Work on Tight Waist with Growing Age

Can Steroids Be Used To Treat Any Conditions?

What are Steroids?

Steroids are actually currently in place to treat medical conditions in both men and women. Men with low libido, hair loss, erectile dysfunction, or otherwise low T levels can be prescribed creams, gels or pills to take to correct these issues, with many men feeling back to their old selves within a matter of weeks.

While over the counter steroids aren’t approved for female use they are approved in certain medical scenarios with a doctor’s prescription. Women experiencing severely low libido issues, pre or post-menopausal women, or treating delayed puberty.

Must Read: 4 Diseases We Can Treat with Steroids

How Will Steroids Affect my Sex Life?

In most cases, steroids have no negative effects on the sex drive. Commonly testosterone will up your libido and cause you to have harder and longer lasting erections. These effects will also give you more drive in the bedroom that will affect everyone differently.

While rare, it can have adverse effects. If you find that instead your sex drive is reduced you should consult with your medical practitioner. You may need to consider using different steroids or stop altogether to avoid any long-term damage.

Must Read: What Are The Best Drugs For Pro-Sexual Effects?

Are Steroids Addictive?

Are Anabolic Steroids Addictive

Steroids are actually considered addictive because they do come with withdrawal symptoms. While most users are able to avoid any long-term addiction symptoms if you have any mood disorders like depression, ADHD, bipolar disorder, you should probably avoid steroid use altogether as the withdrawal symptoms can become overwhelming in these individuals.

Withdrawal will happen during your off-weeks and each cycle can become more intense. These symptoms will include restlessness, sleeplessness, fatigue, reduced sex drive, loss of appetite and depression.

You can reduce your risk of withdrawal by shortening your on-weeks during your steroids cycle and take a longer amount of off-weeks. Also, consider lowering your steroids dose or only taking one steroid at a time instead of a stack.

Must Read: Are Anabolic Steroids Addictive

What To Do Pre-steroids?

Orals or Injected Steroids?

Before starting any steroids you’ll need to make sure your body is physically prepared. It’s important that you make sure you’ve gotten far enough in your bodybuilding that you’ve made every “natural gain” possible first. While it can seem like a good idea to start taking steroids right away it’s not uncommon to wait 6 months to a year as you build up your body.

Another important component of making sure you’re ready is to have a near perfect diet routine. You’ll need to make sure you’re getting the right combination of proteins, carbohydrates, and fats for your body and that you’re getting the proper amount of vitamins and nutrients to support the increase of hormones on your body.

What To Do Post-Steroids?

Most Aromatizing Steroids

It’s important that if you’ve been a long-term user of steroids that you don’t just stop taking them cold-turkey or you’ll probably be left with terrible withdrawal symptoms. You’ll want to wean yourself off your dosage by lowering it considerably and taking it for a week or so to give yourself time to get used to fewer hormones in your system.

You can even do this for a period of on and off weeks if you’ve been used to taking a very high dose or advanced stack. Don't forget to take Tamoxifen or Arimidex for anti-estrogen effect, it is really important.

Steroids are known to be both safe and effective when taken by the safety conscious individual. You can expect your body to gain considerable muscle with an incredible drive.

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Steroids

Decoding IGF-1 LR3: A Guide to its Benefits

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IGF-1 LR3 (Insulin-like Growth Factor-1 Long Arg3) is a synthetic variant of IGF-1, a hormone produced by the liver in response to growth hormone (GH). Unlike GH, which works indirectly, IGF-1 directly facilitates the growth and repair of muscle cells.

Related Article: Ostarine for Beginners; The Ultimate Guide 

This modified version of IGF-1 is engineered to avoid binding with IGF-binding proteins, extending its half-life to 20–30 hours. As a result, it remains active in the body significantly longer than natural IGF-1.

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Many performance athletes incorporate IGF-1 LR3 post-workout to enhance muscle growth, speed up recovery, and support fat loss. When injected into specific muscle groups, it often produces localized effects. Additionally, it helps with nutrient distribution and, in some cases, improves insulin sensitivity.

On the other hand, human growth hormone (HGH) operates more broadly and indirectly, stimulating the liver to produce IGF-1 and offering more systemic benefits such as improved skin health, joint support, and fat reduction, albeit at a slower pace.

Typical IGF-1 LR3 doses range from 20–50 mcg daily, administered subcutaneously or intramuscularly, often following a workout.

Key Features of IGF-1 LR3

Enhanced Bioavailability: It avoids binding with IGF-binding proteins, increasing its potency.

Muscle Growth & Repair: Directly stimulates muscle cell proliferation and differentiation.

Improved Nutrient Distribution: Helps shuttle nutrients into muscle cells, supporting recovery.

Potential Fat Loss Benefits: Some users report improved insulin sensitivity and fat metabolism.

Mechanism of Action

IGF-1 LR3 interacts with IGF-1 receptors on muscle cells, activating pathways like PI3K-AKT and MAPK, which are crucial for cell growth and regeneration. This makes it a powerful tool for bodybuilders and athletes looking to optimize recovery and muscle development.

What Are the Top 10 Alternatives to IGF-1 LR3?

Here are some of the top alternatives to IGF-1 LR3, each with unique benefits for muscle growth, recovery, and performance:

BPC-157 – Known for its regenerative properties, it enhances healing and tissue repair.

CJC-1295 – A growth hormone-releasing peptide that boosts GH levels for muscle development.

Ipamorelin – Stimulates GH release with minimal side effects, making it a safer option.

MK-677 (Ibutamoren) – A potent GH secretagogue that promotes muscle growth and fat loss.

Sermorelin – Encourages natural GH production, supporting recovery and lean muscle gains.

Tesamorelin – Primarily used for fat loss, but also aids in muscle preservation.

Follistatin-344 – Inhibits myostatin, allowing for increased muscle hypertrophy.

PEG-MGF (Pegylated Mechano Growth Factor) – Enhances muscle repair and growth post-exercise.

GHRP-6 – Stimulates appetite and GH release, supporting muscle mass gains.

GHRP-2 – Similar to GHRP-6 but with fewer hunger-related side effects.

Each of these peptides has distinct mechanisms and benefits.

Must Read: Are Nootropics a Better Option to AAS?

Potential Risks Associated With IGF-1 LR3

IGF-1 LR3 comes with several potential risks, especially for bodybuilders using it to enhance muscle growth. Here are some key concerns:

Hypoglycemia (Low Blood Sugar) – IGF-1 LR3 increases glucose uptake in muscle cells, which can lead to dangerously low blood sugar levels if not managed properly.

Organ Growth – Since IGF-1 affects all tissues, excessive use may lead to unwanted growth in organs, increasing health risks.

Cancer Risk – IGF-1 plays a role in cell proliferation, and elevated levels have been linked to an increased risk of certain cancers.

Water Retention & Edema – Some users experience bloating and fluid retention, which can affect performance and aesthetics.

Joint Pain & Stiffness – Excessive IGF-1 levels may contribute to joint discomfort due to increased tissue growth.

Cardiovascular Issues – There is some concern that IGF-1 LR3 could contribute to heart enlargement or other cardiovascular complications.

Desensitization – Long-term use may reduce the body's natural IGF-1 production, leading to dependency

Overall

IGF-1 LR3's ability to bypass IGF-binding proteins makes it more potent but also increases the likelihood of desensitization with prolonged use. For those considering it, careful dosing and monitoring are crucial to mitigate side effects.

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AOD-9604: The Fat-Burning Peptide Explained

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AOD-9604, along with the similar HGH Frag 176-191, is a peptide derived from Growth Hormone that includes only the amino acids in HGH responsible for stimulating fat breakdown, known as lipolysis.

This means that these peptides offer the fat-burning benefits of HGH without its other effects—whether beneficial or adverse—and come at a lower cost.

Related Article: Anavar Cycle for Men and Women 

Lipolysis refers to the process where fat cells are broken down to be utilized as energy. AOD-9604 promotes accelerated fat loss by increasing the body's use of fat as fuel.

For optimal results, the peptides should be used in a fasted state. AOD-9604 and Frag 176-191 are most effective when administered at a dose of 125-250mcg before bedtime (at least 3-4 hours after eating) and in the morning at the same dose, followed by a fasting period of 3-4 hours, ideally combined with fasted cardio.

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Similar Peptides with Fat-Burning Effect

Here’s a list of 10 peptides similar to AOD-9604, each with a brief description:

Ipamorelin: A growth hormone-releasing peptide (GHRP) that stimulates the natural release of growth hormone, promoting fat loss, muscle growth, and improved recovery without affecting other hormones like cortisol or prolactin.

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CJC-1295: A peptide that increases growth hormone and IGF-1 levels, aiding in fat loss, muscle gain, and improved sleep quality. It has a long half-life, making it convenient for users.

HGH Frag 176-191: A fragment of human growth hormone specifically designed for fat-burning. It targets adipose tissue without the broader effects of full-length HGH.

Tesamorelin: Known for reducing visceral fat, this peptide stimulates the release of growth hormone and is often used for weight management and metabolic health.

BPC-157: While primarily known for healing and recovery, BPC-157 can support fat loss indirectly by improving gut health and reducing inflammation.

Melanotan II: Originally developed for skin tanning, it also has appetite-suppressing properties, making it useful for weight management.

Thymosin Beta-4 (TB-500): Focused on healing and recovery, it can enhance physical performance and indirectly support fat loss through improved activity levels.

GHRP-6: A growth hormone-releasing peptide that boosts appetite and metabolism, aiding in muscle growth and fat loss.

Semaglutide: A GLP-1 receptor agonist that regulates appetite and blood sugar levels, making it effective for weight loss and metabolic health.

MK-677 (Ibutamoren): A growth hormone secretagogue that increases growth hormone and IGF-1 levels, promoting fat loss, muscle gain, and improved recovery.

List of Peptides With a Counteractive Effect Bodybuilders Must Avoid

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Some peptides can inadvertently lead to fat gain due to their effects on metabolism and appetite regulation. Here are a few that bodybuilders might want to avoid or use cautiously:

  • GHRP-6 – While it stimulates growth hormone release, it also significantly increases appetite, which can lead to excess calorie consumption and fat gain.
  • IGF-1 LR3 – This peptide enhances muscle growth but can also promote fat storage if not carefully managed with diet and training.
  • MK-677 (Ibutamoren) – Though technically a growth hormone secretagogue rather than a peptide, it boosts GH levels but often leads to increased hunger and potential fat accumulation.
  • CJC-1295 with DAC – While effective for muscle growth, its prolonged GH release can sometimes lead to unwanted fat retention if not paired with a strict diet

Overall

AOD-9604, derived from Growth Hormone, stimulates fat-burning by targeting lipolysis—the breakdown of fat for energy. It delivers these benefits without the additional effects of Growth Hormone, making it more cost-effective. For maximum effectiveness, it should be administered in a fasted state, ideally before bed and again in the morning at 125-250mcg doses. Pairing its use with fasting and fasted cardio can further enhance fat loss. Its sole focus is on improving the body’s ability to burn fat efficiently.

Read More: How Much Do You Know About B-AET? A Fat Burner You’ve Been Missing

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Understanding Trenbolone-Induced Cough (“Tren Cough”)

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Trenbolone, a potent anabolic steroid, can sometimes cause “tren cough”—a sudden and intense coughing episode shortly after injection. Although not exclusive to Trenbolone, it is more commonly associated with this substance due to its highly irritant nature.

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Mechanisms Behind Tren Cough

Solvent and Carrier Irritation

Trenbolone formulations often include volatile solvents like benzyl alcohol or benzyl benzoate, which may irritate lung tissues when absorbed quickly into systemic circulation.

Prostaglandin Release

Trenbolone promotes increased production of prostaglandins, particularly PGF2α. This compound triggers contraction in the smooth muscles of the lungs, leading to bronchoconstriction and coughing.

Micro-Oil Embolism

Tiny oil droplets from an injection can reach capillaries and travel to the lungs, causing mild embolic reactions that lead to temporary oxygen deprivation and coughing.

Histamine and Mast Cell Activation

For some individuals, Trenbolone triggers histamine release and mast cell activation, mimicking an allergic response and causing bronchospasms and cough reflexes.

Related Article: Best Syringes for Steroid Injection on Amazon

Using Salbutamol (Albuterol) to Manage Tren Cough

  • Salbutamol, a widely-used β2-adrenergic receptor agonist, can alleviate tren cough symptoms by:
  • Relaxing bronchial muscles, easing spasms that cause coughing.
  • Inhibiting prostaglandin effects, reducing bronchoconstriction associated with PGF2α.
  • Opening airways, preventing severe respiratory restrictions in susceptible individuals.

Application Methods

Inhaler (Optimal)

Take 1–2 puffs of salbutamol (100–200 mcg) 5–10 minutes before a Trenbolone injection. If coughing occurs afterward, additional puffs can swiftly resolve the issue.

Oral Tablets (Moderate)

Consuming 2–4 mg tablets 30–60 minutes before injection offers slower, longer-lasting relief but may be less effective than inhalation methods.

Nebulizer (Severe Cases)

For individuals with frequent episodes, nebulized doses of 2.5 mg salbutamol can provide substantial relief.

Preventive Measures to Reduce Tren Cough Risk

  • Inject slowly to minimize systemic absorption and irritant effects.
  • Split doses to lower reaction severity with smaller quantities.
  • Opt for ventrogluteal injection sites, which have fewer blood vessels, reducing oil embolism risk.
  • Choose lower-concentration solutions to lessen irritation, as higher concentrations (e.g., Tren Ace 200 mg/ml) are more likely to provoke reactions.

What Other Steroids Can Induce Coughing?

Here's a curated list of peptides, SARMs, and PEDs that may potentially cause coughing or respiratory irritation in bodybuilders and fitness enthusiasts:

Peptides

IGF-1 LR3 (Insulin-like Growth Factor): Known for its anabolic effects, IGF-1 LR3 can occasionally cause mild respiratory irritation due to systemic absorption.

TB-500 (Thymosin Beta-4): While rare, improper injection techniques or high doses may lead to transient coughing episodes.

GHRP-6 (Growth Hormone-Releasing Peptide): This peptide can stimulate histamine release, potentially leading to bronchospasms and coughing.

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SARMs (Selective Androgen Receptor Modulators)

RAD-140: (Testolone) Some users report throat irritation or coughing, often attributed to solvents used in liquid formulations.

YK-11: Known for its myostatin-inhibiting properties, YK-11 may cause mild respiratory discomfort in sensitive individuals.

LGD-4033 (Ligandrol): Though uncommon, some users experience coughing due to carrier solvents or allergic-like reactions.

PEDs (Performance-Enhancing Drugs)

Boldenone Undecylenate (Equipoise): This injectable steroid can cause “Equipoise cough,” similar to tren cough, due to oil embolism or irritant solvents.

Testosterone Suspension: The water-based formulation may lead to coughing episodes if injected improperly or absorbed rapidly.

Nandrolone Decanoate (Deca-Durabolin): While less common, coughing can occur due to histamine release or systemic irritation.

More Tips to Minimize Coughing Risks

  1. Use proper injection techniques to avoid embolic reactions.
  2. Opt for lower-concentration solutions to reduce irritant effects.
  3. Consider antihistamines or bronchodilators for individuals prone to respiratory sensitivity.

Read More: Joint Stiffness: How to Manage It While on AAS

Are There Alternatives to Cough-inducing Steroids?

Here are some alternatives to cough-inducing steroids that can provide similar anabolic effects while minimizing respiratory irritation:

Peptides

IGF-1 LR3 (Insulin-like Growth Factor)

Promotes muscle growth and recovery without the irritant properties of certain steroids.

TB-500 (Thymosin Beta-4)

Enhances tissue repair and reduces inflammation, making it a safer option for recovery.

BPC-157 (Body Protection Compound)

Known for its healing properties, it supports muscle repair and joint health.

SARMs (Selective Androgen Receptor Modulators)

RAD-140 (Testolone)

Provides significant muscle-building effects with fewer systemic side effects compared to traditional steroids.

LGD-4033 (Ligandrol)

Boosts lean muscle mass and strength without the risk of respiratory irritation.

MK-677 (Ibutamoren)

Stimulates growth hormone release, aiding in muscle growth and recovery.

Natural Alternatives

Turkesterone

A plant-based ecdysteroid that supports muscle protein synthesis and recovery.

Ecdysterone

Another natural compound that mimics anabolic effects without the harsh side effects.

Creatine Monohydrate

Enhances strength and muscle mass through improved energy production during workouts.

Other Options

Human Growth Hormone (HGH)

Promotes muscle growth and fat loss, though it requires careful monitoring due to potential side effects.

Testosterone Boosters

Natural supplements like D-Aspartic Acid or Tribulus Terrestris can help optimize testosterone levels for muscle growth.

SARMs Alternatives

Legal and safer versions of SARMs are available, offering similar benefits without the risks associated with traditional SARMs.

Overall

We have explored the phenomenon of "tren cough," a sudden, intense coughing episode often caused by Trenbolone injections due to factors like solvent irritation, prostaglandin release, micro-oil embolism, or histamine activation. Preventive measures such as using salbutamol (via inhaler, oral tablets, or nebulizer), injecting slowly, splitting doses, and opting for lower-concentration solutions were highlighted.

Additionally, alternative compounds to tren cough-inducing steroids were discussed, including peptides like IGF-1 LR3 and TB-500, SARMs such as RAD-140 and LGD-4033, and natural options like Turkesterone, ecdysterone, and creatine. These alternatives provide anabolic effects while minimizing respiratory side effects. The conversation also underscored the importance of proper injection techniques and thoughtful compound selection to reduce risks.

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