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How Steroids Use Affects Tendons

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We all know the great effects AAS have on increasing skeletal muscle, endurance and strength. But how about their impact on tendons and ligaments? Should you be concerned about your tendons health while being on steroids or there is nothing to worry about?

The truth is that over the time steroids use began to be associated with tendons pain and breakdowns. And this is because AAS doesn’t have the same hypertrophy effects on tendons like in case of muscle tissue. Let’s take for example one of the most popular roid among steroid users - testosterone. By injecting testosterone in the body, protein synthesis rises with up to 50% which is pretty good for fast muscle gains. But, it also cuts collagen synthesis at half, causing tendons weakness.

Why Collagen is so important?

Because tendons and ligaments are made up of collagen. The amount of collagen in these structures slightly differ, so that it is found in higher proportion in tendons. Collagen helps strengthen the tendons so that you can work with big weights without damaging them.

By taking steroids protein synthesis increases, body gets stronger and you are able to lift harder and longer. Not the same effect happens on collagen synthesis. And so we get to situation when you build massive muscle mass on tendons unable to hold the big stress. As a result you got tendonitis, a disease that’s not easy at all to treat.

Choose the Right Steroids

The good news is that there are steroids able to improve both protein and collagen synthesis simultaneously. If you already have tendons problems than this is the best way to go with your steroid cycling.

Testosterone is not first option when it comes to tendons. As mentioned above it dramatically lower the rate of testosterone effects on tendonscollagen synthesis, being by far one of the worst steroids for tendons. It may promote amazing muscle gains and improved libido, but you are advised to stay away of it if tendons are your concern.

Winstrol is known to increase collagen synthesis. Indeed, it makes tendons bigger, but also make them brittle. You need strong tendons, but Winstrol is not able to provide it. A lot of people following a light workout program or a cutting one got injured being on Winstrol. Therefore, Winstrol is the LAST choice in your list despite of its benefits.

Sustanon, Cypioanate, Enthanate are poor choices when it comes to tendons safeness.

equipoise for tendonsContrary, Deca-Durabolin, Anavar, Equipoise, Primobolan are steroids to look for when setting up a tendons-friendly cycle. They keep up collagen production while increasing protein synthesis rates. Using them allow you to work out harder for bigger muscle, leaving small even no room for tendons in injuries.

Deca taken in a dosage of 3 gr per kilogram of body weight weekly raises the procollagen III levels by almost 300%. The higher is procollagen III level the more collagen is produced. So, deca is great option as it offers everything you might want: improved collagen synthesis and faster rates in muscle gains.

Equipoise taken in the same dosage as deca (3 gr per kilogram of body weight) increases the procollagen III levels by 350%, while Primo is less effective (180%) but still a very good option.

These steroids should be the basis of any cycle oriented to muscle and tendons strengthening. The main issue with them is that they lower natural testosterone level, so that you have to think about a solution. Adding a minimal dosage of test (100-200 gr weekly) to any of these cycles will maintain the natural testosterone production in normal ranges with minimal or even no impact on collagen synthesis. Going with higher dosage than 200 mg weekly is risky as it inhibits the collagen synthesis.

Pay attention to their half- lives when planning PCT. They have longer half-lives compare to other anabolic steroids. Here they are:

-Deca: 2 weeks
-Equipoise: 2 weeks
-Primobolan: 10.5 days
-Anavar : 8 hours.

Conclusion

After reading this article you have to retain that some of steroids do cause tendon weakness, because they inhibit the collagen synthesis process. Steroids like Winstrol, testosterone, Sustanon, Cypioanate, Enthanate are better to avoid if want to kepp your tendons healthy.

On the other side, steroids like Deca-Durabolin, Anavar, Equipoise, Primobolan help to gain substantially muscle mass while keep up the collagen synthesis. Adding a minimal dosage of test to any of them would maintain the natural testosterone production with no negative impact on collagen production.
However, expecting impressive muscle gains, like in case of testosterone based cycles, would be wrong. Be aware of this next time you plan your cycle.

 

Building muscle is what i like to talk about. If your aim is to build a solid body, then my posts would be very beneficial to you. I always want to know your opinion, so don't hesitate to drop a line below or contact me on my G+ or Fb page.

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3 Comments

3 Comments

  1. David

    August 25, 2017 at 4:10 am

    What studies back up your poistion ?

  2. F Kyle

    August 27, 2017 at 9:44 am

    Personal experience David 😉

  3. David

    April 15, 2018 at 5:16 pm

    I’ll be more specific… How do you know testosterone cuts collagen synthesis by half? Is there a study to base this conclusion on?

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The Role of PGF2a in Muscle Growth

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Role of PGF2a in Muscle Growth

Prostaglandins are an essential part of the substances known as eicosanoids. Nevertheless, eicosanoids are a particular group of substances that are sourced out from fatty acids. These also have been known to include leukotrienes, thromboxanes, and prostaglandins.

Role of PGF2a in Muscle Growth

These have all been formed from the precursor fatty acids with oxygen atoms incorporated into the fatty acid chains. Prior to this reaction, it is known as oxygenation. This is also specifically carried out by the cyclooxygenase enzymes. The metabolites of prostaglandins have been found in the tissues of the body.

Prostaglandins Discovered In the Year of 1930:

Prostaglandins Discovered In the Year of 1930

Prostaglandins have been discovered including their structure in the year of 1930. New York gynecologists have observed that the seminal fluid of humans stimulates the contraction of the isolated uterine muscle.

It was then confirmed in a report that the seminal fluid produces contraction in the intestinal smooth muscle. This is also mainly responsible for lowering the blood pressure after being injected into the bloodstream.

Prostaglandins Role in the Body:

Prostaglandins Role in the Body:

 

Prostaglandins have their essential role to play in the body. They are basically classified as the autocrine and paracrine regulators.

Actually, they do not fit into the classification of hormones. One thing you will need to understand is that they are a corollary of the so-called endocrine system.

PGF2a Increases the Signaling Pathways of Calcium and the Intracellular Calcium:

PGF2ais known to increase the signaling pathways of calcium and the intracellular calcium. These are somehow essential as part of the many different stages of myogenesis that help in the success of muscle growth. It was further hypothesized that the PGF2acould regulate the growth of the skeletal muscles.

Its role is also further investigated in some other myogenesis steps requiring calcium that include fusion and differentiation. It is also believed that PGF2acould enhance the myonuclear accretion right after the myotubes have been formed. This now leads to an increase in the size of the myotube.

However, the growth brought by PGF2acomes out via an NFAT-dependent pathway. Prior to these data, these only implicate a novel function for the PGF2ain the growth of the skeletal muscles. However, there is also a novel intersection between NFAT signaling pathways and prostaglandin.

PGF2a Increases the Nuclear Number and Muscle Cell Size:

The hypothesis suggesting that PGF2ahaving an essential role to play in the growth of muscle cells involved the differentiation of the main muscle cultures. They were treated with PGF2adoses or a synthetic analog of the PGF2a.

After twenty-four hours, most of the cells have been differentiated. They have also been known to form several multinucleated cells.

Even if there is no such thing as difference seen between the drug-treated and vehicle-groups at twenty-four hours, after forty-eight hours, the myotubes that were treated with a drug are bigger in size than the vehicle. This only suggested the fact that PGF2acould regulate the muscle growth.

PGF2aIncreases the Size of Myotube:

PGF2aincreases the size of myotube as it facilitates the fusion of muscle cells. In the fusion of the myoblasts, it creates a multinucleated cell. The growth of cell occurs by way of the fusion of various muscle cells with a nascent myotube.

This increases the cell size and the myonuclear number. In the treatment of 10-6  M PGF2a, an increase occurred in the myotubes percentage with 5 or even more nuclei. There was also a parallel decrease in the so-called percentage of myotubes with 2 to 4 nuclei.

Prior to this dose, it has been shown to bring out maximal effects using smooth muscle and cardiac cells. The data suggested that it could increase cell fusion with the myotubes that help facilitate an increase in the size of the muscle cell.

The Mediated Muscle Growth of PGF2aOccurs Via FP Receptor:

In determining the role of endogenous PGF2ain regulating the myonuclear accretion, cells were applied with a competitive and selective FP antagonist.

In that data released, it suggested that PGF2a muscle growth induced is mediated by way of an FP receptor. And, the endogenous PGF2ais needed for the growth of muscles.

PGF2a Increases the Myotube Size by Way of a Dependent Pathway of NFAT:

The main myoblasts were actually infected by way of a control retrovirus or a retrovirus that expresses VIVIT. The NFAT transcriptional activity was further analyzed in the cells that contain an NFAT responsive luciferase reporter construct.

The activity of a luciferase is further increased in the cells that have been treated with the 10-6 M PGF by ninefold. The combination of these data highlights that PGF2aactivates the NFAT signaling in the skeletal muscle.

PGF2a Induces the Growth of Muscles:

Induces the Growth of Muscles

PGF2ainduces the growth of muscles. And, the specific agonist of FP receptor can activate an increase in the nuclear number and myotube size that is the same with PGF2a.  The growth of muscles is inhibited by the AL-8810 which is a particular FP receptor antagonist.

Other Studies Demonstrate PGF2a:

There are also other studies that demonstrated PGF2aand its role in increasing protein synthesis in the skeletal muscle cells. It also further activates both protein synthesis and cell fusion. This could also regulate hypertrophy of the skeletal muscles.

Now, you have learned the role of PGF2a in the muscle growth!

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Nutrition

A New Caffeine? What You Need to Know about Teacrine

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new caffeine

What do you know about Teacrine? This is actually described as a new ingredient utilized in pre-workout formulas. And, there were already many types of research and studies conducted to help you understand more about this supplement and how it could help you.

Caffeine Introduced as One of the Most Legal and Most Effective Ergogenic Aids:

Caffeine is considered to be one of the most legal and most effective ergogenic aids. This is also believed to be the main ingredient in most pre-workout supplements that could be purchased on the market. It is just that there might be an issue with caffeine. One will also build up his or her tolerance.

Related Article Must Read:  Caffeine

Remembering the First Day of Pre-Workout and Thinking of an Aid Training:

Remembering the First Day of Pre-Workout and Thinking of an Aid Training:

You may have remembered the very first of your pre-workout. You slammed the door and walked into the gym. And, you felt like you could do anything on the ground. It is just that you realize of dying from an anxiety attack.

After taking the same supplement, it is like you’re feeling a little of your energy. Actually, you will need to have an ideal supplement to help you in your training.

This could, of course, bring out the same effect just like caffeine but with no habituation. You would want to have a hundredth dose to get the same feeling as of the first dose. This is the time that teacrine will be one important thing to consider.

What Exactly is a Teacrine?

 

teacrine

Teacrine is basically described as a small-sized molecule that is found in most plants. This also has the same molecular structure like the caffeine. This is actually sourced out from caffeine. Other than the plants, it is manufactured synthetically in most laboratories for the purpose of sports performance, behavioral modification and research purposes.

Considering the fact that the chemical structure it has is the same with caffeine, it just functions the same in the body. This has its specific mechanism of action that changes the brain’s adenosine signaling. This is exactly how caffeine really works.

One more thing about it is that it impacts the dopamine level of the brain. This somehow brings its small effects especially in improving the mood. Another interesting thing about teacrine is that it looks more resistant to the development of tolerance as compared to caffeine. The habit of drinking caffeine usually occurs in just several days.

Teacrine Fills the Role:

You will need to understand the fact that you could definitely be one-hundred percent on your game, twenty-four hours a day and seven days in a week. You will always need one thing that will help you push yourself up through hard workouts or long days.

With caffeine, it will get you rolling on your work until four in the morning. It will also be useful in powering you throughout your mid-afternoon slump. On the other hand, teacrine could fill this role. This will allow you to consume it without escalating your dose.

In a particular study conducted, it was discovered that teacrine could bring out a huge promise being a caffeine replacement. In a placebo study, people who consumed two-hundred milligrams of teacrine experienced an even lower level of fatigue. In an independent study, the same findings were also even shown.

Teacrine Can be Considered as a Supplement for Sports Performance:

Teacrine is known to show the same effects considering fatigue in most people. This also works the same with caffeine. This only means to say that Teacrine is a great supplement when it comes to improving training.

With just 200 milligrams of teacrine, it could already help reduce fatigue. Doses of 275 milligrams will already increase the time spent to exhaustion. This means to say that you could already train for over a long period of time.

The upper end of dosing has not yet been established. It is not yet known as well if consuming more will already be equal to more performance. Or, it could have been possible that it will just only be a waste of supplement.

Click Below to Find out More & Price of Teacrine

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Pairing Caffeine with Teacrine:

You need to understand the fact that caffeine and teacrine work the same way. In a published study, it demonstrated that teacrine consumed with caffeine increases the supplementation of teacrine and its efficiency.

Will Teacrine Kill You?

If you will train hard and you will go on a beast mode, both can still be considered as legit. If you will die because of consuming something that is crazy, you will just experience the loss of your gains. If you will try a new supplement in the market, it is a must to ensure its safety.

Teacrine Promises Safety:

In all these, teacrine is highly emphasized to be safe and secure. This is especially true for most hungry and young gym goers. In fact, scientists took sixty men during their late teens including early twenties.

They were given with three-hundred milligram of teacrine, a two-hundred milligram of teacrine and placebo for two months. They were observed if something happened in their hearts including their overall metabolism.

It was found out that nothing crazy happened considering their glucose or blood lipids. Even their breathing was fine and their resting heart rate was solid. Their resting blood pressure was also just fine. Teacrine indeed passed the tests with flying colors. It was truly safe, so far.

Conclusion:

For that one-solid supplement to help you through a tiring and stressful afternoon, it will be a good idea to try Teacrine. This will give you something such as a steady focus including a little pep in your routine. Teacrine will be the best and most potential supplement to replace the role of caffeine.

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Nutrition

How do You Suppress Your Appetite While Cutting?

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How do You Suppress Your Appetite While Cutting?

How do you suppress your appetite while cutting?In any method of dieting, you want to stick to, you will need to really discipline yourself. Fat loss will always come down to just one thing: maintaining a calorie deficit by burnings more fats and calories. Actually, this is best known as the “Law of Energy Balance”. In fact, this is regarded as the ultimate foundational principle in any of the fat burning program. When you take in just a few calories, your body will be forced to tap into the excess fats to get the desired energy.

What Happens When the Caloric Expenditure Exceeds the Caloric Intake?

What do you think will happen when the caloric expenditure exceeds the caloric intake of an individual? This will end up in the body naturally kicking into a survival mode. This will, therefore, bring out the feelings of starvation and hunger.

Thus, you will feel more motivated to eat. As per this response, this will usually be hard-wired and automatic. This will also make you feel uncomfortable. There will really be no way out. Some people consider these hunger feelings as difficult for them to deal with and more intense.

Others also consider these as something less intense and a small problem.

Two Things Are For Sure:

There will always be two things that are for sure to happen:

  • Food cravings will be the #1 reason why people fall off their track considering their diet on fat loss. They will just end up failing and not achieving their goal in the long time period.
  • If you will put your body into such a deficit in calorie, expect to feel hungry

Effective Tips to Employ:

There will always be some effective tips to employ on how you suppress your appetite while cutting. That way, you will minimize the hunger that you experience all throughout the cutting phase. And thus, you maximize the chances of eliminating more fats. Even if these tips may not totally eradicate the hunger levels that one has, these will still bring a significant difference in life. These will help reduce the fats down to an even more manageable situation.

Concentrate Further on Losing More Fats:

This is a number one tip that you will need to keep in mind. This is also even regarded as the most important of them all. But first, you need to create a large calorie deficit. This will not just let you lose a lot of muscle mass, this will help you to feel hungrier than before.

In this regard, think of fat loss as something as a marathon. Just concentrate on creating a small deficit of calorie that will eliminate the fats away. You will also specifically maintain a lean mass and will keep your hunger levels in control.

A strict guideline will need to be followed like employing a calorie deficit of about fifteen to twenty percent below the maintenance level. Focus on losing about one to two total pounds every week.

Must Read:: Primobolan Cycle Lean Mass Fast Fat Burning Agent

Never Let the Intake of Dietary Fats Drop Too Low:

One of the myths that you should not ever believe is that dietary fat will make you fat.  You need to keep in mind that maintaining the adequate intake of fats is essential as part of the overall plan. With enough dietary fat, you help keep yourself maintain testosterone levels from going low. This will help you as well to feel fuller and even more satisfied. This will help slow down the rate of the so-called gastric emptying.

In this regard, you need to get twenty percent of the total daily calories coming from fats. Actually, fats contain about nine calories for every gram. If your daily intake of calorie is 2200, you will need about fifty grams of fats every day.

Eat Lots of Fiber:

Eat Lots of Fiber:

Fiber is known to absorb water while it passes through the digestive tract. This will essentially expand and gel in the stomach that will increase the feelings of satiety and fullness. Just the same with fats, fiber will slow down the possibility of gastric emptying.

Increase your fiber consumption by way of consuming fruits and fibrous vegetables. There are also other food sources like whole grains, seeds, nuts, barley, potatoes, and oatmeal. It will also help if you eat up about fifteen grams of fiber for one-thousand calories.

Eat a Lot of Vegetables:

Eat a Lot of Vegetables:

Vegetables will always be the best sources of a diet towards losing fats. This is due to the very reason that they are high in their volume and low in their calories. Eating vegetables along with other meals the entire day will help you fill yourself up. You will also keep your calorie content down.

With three cups of lettuce, you will be amazed as these already contain about twenty-five calories. With two cups of sliced mushrooms, these already consist of around thirty calories.

Always remember that vegetables will help reduce the hunger of a person. They are also believed to be incredibly micronutrient dense.

Increase Your Intake of Water:

Intake of Water

In addition to drinking a lot of water the entire day, you also need to stick to consuming more glasses of water. This will need to be done with every meal. That way, you will be able to increase your overall satiety.

Find Balance between Cardio and Dieting:

Fat loss will be achieved by maintaining a deficit in calorie intake. This will be done by burning a lot of calories consumed. Consume less food and increase your activity level. Or, if you want, combine both. By reducing the body’s calorie intake and increasing calorie expenditure, you will be on your way to stimulating the appetite.

But remember, each one reacts differently. There are some who can manage their hunger effectively by creating an even bigger calorie deficit. This will be made possible by way of performing less cardio exercise and diet. There are some who consume a lot of calories to perform a high-intensity cardio exercise. Actually, both of them can bring out the same deficit.

Now, you have learned more about the tips on how you will suppress your appetite while cutting!

Must Read: The Do’s And Don’ts Of Low And High-Intensity Cardio

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