Steroids

Why Use Antioxidants During a Steroid Cycle.

Published

3 years ago

March 9, 2021

Antioxidants During a Steroid Cycle

Steroids are synthetic hormones designed for clinical use in managing various chronic diseases. Anabolic-androgenic steroids, derivatives of the male hormone testosterone, are used by athletes in sports. The aim in such instances is to boost muscle mass and increase performance and endurance. Also, they shorten recovery time between exercises. Inappropriate use of steroids is associated with several adverse effects. Their correct use is recommended to limit such outcomes, and antioxidants can help you.

Due to the varied uses and different desired outcomes, patterns of use have been established; cycling, stacking, and pyramiding. The steroid cycle refers to a pattern of steroid use intending to build body or muscle mass. Here, anabolic androgenic steroids are used in six to twelve weeks, followed by an off phase of several months. Pyramiding generally involves gradually increasing the dose of the steroids to a maximum level, followed by dose reduction. Another pattern is stacking, where various steroid combinations include other supplements.

Steroids in Sports

Athletes' desired outcomes categorize steroids as either bulking steroids- used to increase muscle mass or performance steroids- aimed to increase strength and endurance. Or cutting steroids- used to reduce weight (cut fat). Delivery routes are based on user preference and desired outcome. It can be oral, implants, injections, and creams or gels. They bind to the androgen receptors in the body, resulting in molecular interactions with the cell DNA. The ultimate result is to increase protein synthesis and subsequent cell growth.

Cycles for anabolic steroid use depend on the physical state of the user. Beginners and experienced users have different cycles. This limits the chances of developing adverse outcomes; for instance, it lowers the risk of suppressing one's hormone production. Also, it enhances higher efficiency and safety. An example of a steroid cycle for beginners includes turinabol 30-50mg/day for 9 weeks, testosterone enanthate 500mg/week for 8 weeks, and Dianabol 30-50mg/day for 6 weeks. Experienced athletes' cycle contains a combination of steroids, for example, nandrolone decanoate +sustanon, trenbolone enanthate plus testosterone, and boldenone plus testosterone enanthate.

What are Antioxidants?

Antioxidants are substances or elements that inhibit or reduce cell damage due to free radicals, reactive oxygen species, and other unstable molecules resulting from chemical reactions or physiological changes in the body. During a steroid cycle, antioxidants play a role in scavenging free radicals and other unstable compounds produced by skeletal muscles during exercise.

The roles played by these antioxidants include;
Prevent oxidative stress.
Reduce exercise-induced muscle damage.
Increase muscle endurance.
Shorten the recovery time after exercise.
Counteract neutrophil inflammatory response.

The roles listed above are discussed in detail as follows. Later, I will discuss various classes and types of antioxidants available.

Antioxidants Counteract the Effect of Oxidative Stress.

Antioxidants cushion the oxidative stress sequelae. Physical exercise increases the production of reactive oxygen species, nitrogen species, and free radicals and their accumulation within the muscle mass. A sustained balance between oxidation and reduction is important in maintaining muscle physiology. These reactive oxygen species comprise superoxide anions, hydroxyl radicals, and peroxyl radicals.

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Oxidative stress results from an imbalance between free radical production and the eliminating of physiological antioxidants. This imbalance with increased radical levels accounts for oxidative damage. Stress-sensitive signal pathways are activated, which play a role in the pathogenesis of chronic conditions such as cardiovascular conditions, metabolic syndrome, and insulin resistance.

Physical exercise's physiological importance in maintaining normal body function and health is accompanied by oxidative stress induction. During physical exercise, there is an increased demand for oxygen in the muscle tissue. It is estimated that oxygen uptake by the muscles increases by 10-20 folds. This increased influx in active skeletal muscles increases the formation of reactive oxygen species and free radicals. Their effect is to oxidize macromolecules, DNA, amino acids, polyunsaturated fatty acids, and proteins.

Basis of Antioxidants

The oxidized molecules form the basis for the development of chronic diseases. Reactive oxygen species accumulation results in muscle dysfunction and damage, prolonging recovery time. Antioxidants must counter these effects by eliminating formed reactive oxygen species and free radicals.

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Increased muscular activity is accompanied by increased metabolic rate and increased oxygen consumption by muscle fibers. This results in a subsequent temperature increase and reduced cellular muscle mass pH. These changes enhance free radicals' formation and accumulation in the muscle cells. Antioxidants protect the body from oxidative damage by reactive oxygen species and free radicals. Antioxidants protect against muscle damage.

During the steroid cycle, muscular activity increases with increased exercise levels. During this activity, muscle fibers stretch as a result of repeated use. Repeated contractions and relaxation create tension in skeletal muscles, causing the fibers to lengthen. Physical exercise increases oxygen influx within the muscle tissue. These active muscle fibers increase in size approximately by 100-200 folds. Normally, muscle fibers are adaptive to the level of stress experienced.

However, increased activity increases the production and accumulation of free radicals and reactive oxygen species. Their formation rate exceeds that of clearance by available antioxidants, both exogenous and endogenous systems. Their formation plays a role in muscle damage during physical activity. Antioxidants remove the reactive oxygen species, thus halting further muscle damage. A study by Cian McGinley et al. 2009 evaluated vitamin C and E's role in preventing muscle damage due to ROS due to exercise among sportspersons.

New studies on Antioxidants

The study used various supplementation mechanisms with variations in dosing, timing, and duration. The study's outcome showed that antioxidants reduce oxidative stress with a minimal role in preventing muscle damage. A similar study by Vilma Simoes Pereira et al. in 2015 aimed to find the effects of supplementation with dietary antioxidants on recovery following exercise-related muscle damage.

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Dietary supplementation of phytochemicals has been shown to reduce the effects of eccentric muscle damage due to exercise. Another study explained the findings above, emphasizing that the correct dosage and requirement should be provided to avoid toxicity or causing further muscle damage. An individual estimated requirement must be provided for muscle tissue's effective functioning and a better outcome.

Role in Modulating Inflammatory Response.

During the steroid cycle, individuals are involved in strenuous physical exercise. This activity alters the skeletal muscle state by increasing the length and that of tendons. This is a result of the adaptive activity of the muscle tissue to exercise, as discussed above. In the process, there is a muscle injury, which will trigger an inflammatory response. Muscle damage also results from the thermal effects and ischemia/reperfusion. Neutrophil leads to the accumulation of reactive oxygen species, thus increasing the burden of oxidative stress in the muscle cells.

Neutrophils are increased in circulation during exercise. Their increase subsequently increases the level of neutrophils associated with reactive oxygen species and corresponding oxidative stress. Another source of neutrophils during exercise is suggested to be the effect of free radicals on leucocytes, where they damage the DNA. A study confirmed that antioxidants modulate the neutrophil inflammatory response to exercise-induced stress.

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In that study dated December 7th, 2020, three groups were studied for 21 days. One group was on the antioxidant-supplemented beverage, and the others acted as control groups. Blood samples were drawn at the end of the exercise, and plasma and neutrophils were separated. Plasma creatinine kinase and myoglobin levels have elevated a confirmation of muscle damage due to exercise.

After measuring plasma oxidative bio-markers, it was found that it increased in all the groups, not on antioxidant supplements. On measuring neutrophil antioxidant enzymes, there was a notable increase in the control groups, confirming that the activity was reduced in the supplemented group. The activity of myeloperoxidases was increased significantly among the control groups. On the other hand, enzyme levels were elevated among those on antioxidant supplements. This confirmed the role of antioxidants in modulating inflammatory responses induced by exercise.

Increase muscle endurance and recovery and reduce recovery time.

Selected antioxidants have been shown to increase muscle endurance by reducing the delayed onset of muscle soreness. Polyphenols and other commercial antioxidants have been shown to have a moderate to good effect in lowering the delayed onset of muscle soreness. Other antioxidants have been shown to affect post-exercise muscle recovery positively. The ROS-scavenging effect of antioxidants reduces the number of free radicals and reactive oxygen species in skeletal muscles during exercise. These changes reduce muscle damage and thus increase muscle endurance during exercise. The formation of free radicals within the skeletal muscle has beneficial effects—the produced reactive oxygen species act as signaling pathways to enhance muscle protection from further physical stress.

Antioxidants

As defined above, they are free radical scavenging molecules. The overall effect of this function in to protect the cells from oxidative stress-induced damage. Their interaction with free radicals results in a chemical reaction that stabilizes these free radicals. In other words, the molecules can prevent oxidation or limit oxidation of other molecules. Oxidation refers to a chemical reaction that involves the transfer of electrons from one compound or element to the other (oxidizing agent).

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These reactions act as a source of free radicals, which start a chain of other harmful reactions to the cells. Antioxidants are mostly reducing agents in nature, thus preventing oxidation reactions by them getting oxidized in the process. A lack of antioxidants in the body or their limited availability will result in an oxidative stress state. This state is associated with a series of reactions that damage the cells and compromise function. Free radicals are associated with the pathogenesis of chronic diseases, for instance, cardiovascular diseases and cancers. Supplementation of antioxidants is beneficial because it provides the body's optimal physiological function and improves health.

Antioxidants can be endogenous or exogenous. Physiological antioxidants are naturally present in the body and comprise superoxide dismutase, catalase, and glutathione peroxidase. Exogenous antioxidants must be provided through an antioxidant-rich diet, synthetic antioxidants, and other supplements. Examples include thiols, vitamins C, E, and A, and polyphenols. Antioxidants can also be grouped as: 1. Natural antioxidants (primary), and 2. Synthetic antioxidants (secondary).

Primary antioxidants (free radical scavengers)

These antioxidants stabilize free radicals. They achieve this by breaking the chains of lipid radicals and converting them to a non-radical state or stable form. This group comprises antioxidants derived from phenols and secondary aromatic amines. Their structure makes them available in different molecular weights. They are further grouped as either mineral antioxidants, vitamin antioxidants, or phytochemicals. The mineral antioxidant serves as co-factors to enzymes involved in the anti-oxidation process. They comprise selenium, iron, zinc, magnesium, and copper.

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Their availability plays a bigger role in macromolecules' metabolisms, such as proteins and carbohydrates. Vitamins and antioxidants are vitamins that act as reducing agents. This comprises vitamins B, C, and E. Antioxidants that cannot be grouped as minerals or vitamins fall in the phytochemical category, including flavonoids. They are phenol compounds responsible for the coloration of plants, i.e., fruits and vegetables or seed leaves.

The most active in this group are catechins found in green tea and sesamol. The fat-soluble color of vegetables and fruits forms carotenoids. An example is beta-carotene, which is found in carrots in the body. It serves as a source of vitamin A in case of deficiency. Tomatoes have lycopene as an antioxidant, while dark green vegetables have zeaxanthin.

Secondary Antioxidants (peroxidase scavengers)

Unlike primary antioxidants, these function by reducing or decompressing hydroperoxides into stable compounds before transforming into active free radicals and stopping the chain reaction. The action can be combined with primary antioxidants for synergism and effective oxidative stress management. Examples include; Nordihydro garlic acid, tertiary butyl hydroquinone, butylated hydroxytoluene, propyl gallate, metal chelating agents, and butylated hydroxyanisole.

Sources of antioxidants.

The leading source of antioxidants is fruits and vegetables. Antioxidants are also available in nuts, grains, and animal proteins. Alpha-tocopherol is found in sunflowers, almonds, corn, broccoli nuts, and mangoes. Vitamin A-rich foods include liver, sweet potato, carrot, milk, egg yolk, and cheese. Ascorbic acid is found in most fruits and vegetables.

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Color-containing fruits and vegetables, especially oranges color, are rich in beta-carotene. Green vegetables have an abundance of lutein and zeaxanthin. Tomatoes and their products contain high levels of lycopene. Mineral antioxidants are provided as supplements or other available in plants and animals, for example, selenium (rice and wheat).

Properties of antioxidants

Antioxidants used mostly are phenol compounds, either monohydroxyl or polyhydroxy. Due to their low activation energy, they are not reduced (they would not donate hydrogen). As a result of this stabilization, it prevents the formation of other free radicals. A free radical chain reaction is minimized by donating hydrogen by the antioxidant. The intermediate antioxidant free radical does not oxidize due to its stability, thus preventing free radical chain reaction propagation. The resultant antioxidant radical can also react with lipid-free radicals, and a complex compound is formed, which is stable, thus preventing further damage by such radicals.

Examples of antioxidants

Vitamin E (tocopherol): this is a fat-soluble antioxidant. Among the eight members of this group, alpha-tocopherol is the most important. It is the most lipid-soluble and enhances the membranes' protection from lipid-related free radicals resulting from lipid peroxidation chain reaction. The intermediate of this reaction, oxidized alpha-tocopherol, can be recycled to its original form using other antioxidants, e.g., vitamins A and C.

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Vitamin C has reducing properties, can neutralize reactive oxygen species, and plays a vital role in cancer prevention. Its reaction with glutathione within the cell maintains it in a reduced state.

Glutathione is synthesized in the cells from amino acids. It can be maintained within the cell in either reduced or oxidized states mediated by enzymes such as glutathione reductases. It maintains the cell in its redox state, and due to its high concentration, it is the most vital cellular antioxidant. The cysteine group has reduction properties in its structure and can be oxidized reversibly.

Adverse effects of antioxidants

Toxicity in case of antioxidant overdose.
Reactive oxygen species (ROS) regulate cell adhesion, and their elimination compromises this.
ROS regulates the MAPK pathway for DNA repair. antioxidants actions will inhibit DNA repair and apoptosis
Immune system activation depends on ROS, and so does inflammatory response induction.
ROS plays a role in killing phagocytosed microbes by macrophages. Their elimination by antioxidants will impair this role.
Activation of the extracellular microbes depends on superoxide and nitric oxide, which eliminate antioxidants.

Conclusion

Contrary to what many people think about antioxidants, they’re, in fact, beneficial to a bodybuilder or any other fitness enthusiast during a steroid cycle. However, it would help if you regulated it to reap the full benefits.

Related Topics:Antioxidants Steroid Cycles

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Anabolic Steroids

How Much Do You Know About B-AET? A Fat Burner You’ve Been Missing

Published

18 hours ago

May 18, 2024

SaneNt

Introduction to B-AET

B-AET, or Beta-Androstenetriol, is a DHEA derivative known for its impressive health benefits, including anti-catabolism and fat loss. Despite its advantages, it remains largely unknown because it is hard to obtain, not due to any significant drawbacks.

Let’s delve into its properties:

Anti-Catabolic Effects: B-AET helps prevent muscle breakdown (catabolism). By preserving muscle tissue during intense workouts or calorie deficits, it supports overall fitness goals.

Fat Loss Potential: B-AET may enhance fat loss. While the exact mechanisms aren’t fully understood, it likely influences metabolism and fat utilization.

Challenges with Availability: As we've mentioned, B-AET is not widely accessible. Its scarcity limits research and popularity.

Comparing B-AET to 7-KETO DHEA

Similar to 7-KETO DHEA, B-AET does not suppress the HPTA and promotes fat loss by inhibiting cortisol. Based on personal experience, B-AET offers superior results compared to 7-KETO DHEA.

Must Read: 10 Week Program & 5,000 Rep Arm Specialization Program

Understanding Cortisol’s Role in Fat-Loss

Cortisol, released in response to stress, was crucial for survival in our evolutionary past. However, in today's world, chronic stress leads to persistently high cortisol levels, contributing to various health issues including fat accumulation, especially around the abdomen, insulin resistance, muscle loss, increased blood pressure, weakened immunity, impaired memory, decreased bone density, inhibited collagen synthesis, hair loss, depression, and lower testosterone levels.

Benefits of Beta-Androstenetriol

B-AET helps with fat loss by inhibiting cortisol production through the suppression of the enzyme 11β-HSD1. Users often notice significant fat reduction, especially around the lower belly. Additionally, B-AET lowers overall stress, enhances immune function, prevents muscle loss during calorie restriction, and has anti-inflammatory properties.

B-AET helps prevent muscle breakdown during intense training, preserving your hard-earned muscle mass.

By supporting muscle preservation and potentially aiding fat loss, B-AET can optimize overall performance during cutting phases.

Potential Side-Effects of Beta-Androstenetriol

Data on B-AET’s side effects is limited. Anecdotal reports suggest minimal side effects, but overuse could potentially lead to decreased stress response, fatigue, and low blood pressure due to chronically low cortisol levels. However, these risks are minimal if B-AET is used properly.

Let’s explore the potential dangers associated with Beta-Androstenetriol (B-AET) in detail:

Limited Research: As mentioned, B-AET remains relatively unknown due to limited research. Lack of comprehensive studies makes it challenging to fully understand its safety profile and potential risks.

Individual Variability: As with any compound, individual responses can vary. What works well for one person may not be suitable for another. Always consider your unique physiology and consult a healthcare professional.

Side Effects

Gastrointestinal Disturbances: Some peptides can affect the digestive system, leading to nausea, vomiting, diarrhea, or stomach discomfort. While these side effects are typically transient, they’re worth noting.

Appetite and Blood Sugar: GHS peptides (including B-AET) may increase appetite and blood sugar levels.

Fluid Retention: Fluid retention is another possible side effect.

Legal Status: B-AET’s legal status varies by region. Ensure compliance with local regulations and restrictions.

Dosage and How to Use B-AET

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B-AET can be taken orally or applied topically. Due to poor bioavailability when taken orally, the topical application is far more effective and may offer localized benefits. Let’s explore dosage and usage in detail.

Dosage

Unfortunately, there isn’t a universally established dosage for B-AET due to limited research and availability.

If you decide to use it, start with a conservative dose and gradually increase if needed.

Consult a healthcare professional or a knowledgeable coach who understands peptide usage.

Usage

B-AET is typically administered via subcutaneous injections.

Follow these general guidelines:

Frequency: Inject once or twice daily.

Timing: Some users prefer morning injections to align with natural cortisol rhythms.

Cycle Duration: Cycles can vary from a few weeks to several months.

Stacking: B-AET can be stacked with other peptides or compounds for synergistic effects.

Always:

Rotate Injection Sites: Avoid injecting in the same spot repeatedly.

Reconstitute Properly: If using lyophilized powder, follow reconstitution instructions.

Store Correctly: Keep B-AET refrigerated to maintain stability.

Other Fat-burning Alternatives to Consider

Also Read: 5 Steroid Cycles for Beginners

As a bodybuilder looking to optimize fat loss, consider incorporating the following peptides into your regimen:

Amlexanox

Function: Originally used for oral ulcers, Amlexanox has shown potential for fat loss. It activates an enzyme called AMP-activated protein kinase (AMPK), which plays a role in energy regulation and fat metabolism.

Mechanism: By enhancing AMPK activity, Amlexanox promotes fat breakdown (lipolysis) and inhibits fat storage (lipogenesis).

Administration: Available as a topical gel or oral medication.

Note: Research is ongoing, and its effectiveness for bodybuilders specifically needs further investigation.

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Glycyrrhetinic Acid

Function: Derived from licorice root, Glycyrrhetinic acid has anti-inflammatory properties and may aid fat loss.

Mechanism: It inhibits an enzyme called 11-beta-hydroxysteroid dehydrogenase, which affects fat distribution.

Administration: Often used in topical creams or as a supplement.

Caution: High doses can lead to side effects, so moderation is crucial.

Tesofensine

Function: Tesofensine was initially developed as an anti-obesity drug.

Mechanism: It increases levels of neurotransmitters like serotonin, dopamine, and norepinephrine, leading to reduced appetite and increased fat burning.

Administration: Oral tablets.

Note: Not widely available due to limited research and regulatory hurdles.

AOD9604

Function: AOD9604 is a modified fragment of human growth hormone (HGH).

Mechanism: It stimulates lipolysis (fat breakdown) without affecting blood sugar levels or muscle growth.

Administration: Typically injected.

Caution: Consult a healthcare professional before use.

5-Amino-1MQ

Function: 5-Amino-1MQ is a novel compound with potential fat-burning effects.

Mechanism: It interacts with mitochondria, enhancing energy expenditure and fat oxidation.

Availability: Limited due to being a newer discovery.

Overall

When it comes to burning fat in bodybuilding, a combination of heavy training and cardio is effective. Heavy weights help build muscle and improve strength, while cardio aids in fat loss. Additionally, consider incorporating fat-burning exercises into your routine.

However, if you can lay hands on B-AET and safely, it might just be the product you have been looking for. Good luck as you embark on a journey to get rid of that extra fat.

Related Article: First Injectable Steroid Cycle

Bodybuilding Products

TRT Add-ons: The Ultimate Guide

Published

6 days ago

May 13, 2024

SaneNt

Testosterone Replacement Therapy (TRT) has become a popular solution for men looking to regain their youthful vitality and improve their overall health. However, TRT alone may not be enough to achieve optimal results. That’s where TRT add-ons come in. These additional compounds can enhance the effects of TRT and address specific goals or concerns.

Most bodybuilders may prefer safer natural supplements or synthetic drugs to enhance their TRT (Testosterone Replacement Therapy) without resorting to anabolic steroids. Let’s explore three natural supplements and three synthetic options that can complement your TRT protocol.

Must Read: Steroids That Can Be Used For Joints Or Ligaments Injuries

Natural Add-Ons

1. Saw Palmetto

A mild inhibitor of the 5-alpha-reductase enzyme, it prevents the conversion of Testosterone into DHT.
Useful for hair loss, acne, and preventing benign prostatic hyperplasia.
Take 200 mg daily.

2. Boron

Boron, a mineral found in the periodic table, isn’t strictly essential but offers benefits.
It improves bone health, recovery, and neuroprotection.
Most importantly, it decreases SHBG (Sex Hormone-Binding Globulin) and increases Free Testosterone.
Take 5 to 6 mg per day, with a week off for every two weeks of use.

3. Diindolylmethane (DIM)

Found in cruciferous vegetables, DIM acts as a mild aromatase inhibitor (AI) and improves Estrogen metabolism.
Consider DIM if you tend to aromatize excessively.
Start at 50 mg/day and adjust up to 150 mg/day if needed.

Other Natural Supplements for TRT

Include Vitamin D3, Vitamin K2, Vitamin C, Magnesium, Zinc, and Berberine.

Synthetic Add-Ons

PDE5 Inhibitors (Cialis or Viagra)
- Widely used by TRT users.
- Enhance blood flow, leading to better erections, lower blood pressure, and improved gym performance.
- May increase protein synthesis and muscle building.
- Take 5 to 10 mg of Tadalafil or 25 to 50 mg of Sildenafil as needed.
Cardarine
- Potentially risky in the long term due to rodent cancer studies.
- Short-term use benefits cardiovascular health, insulin sensitivity, fat loss, and endurance.
- Take 10 to 20 mg daily for no more than 8 weeks.

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Peptides
- Numerous useful peptides available.
- BPC-157 and TB-500 aid healing.
- DSIP promotes better sleep.
- Ipamorelin and CJC-1295 act as GH secretagogues.
- Consider peptide therapy through TRT clinics or with a doctor’s prescription.

More TRTs You Can Find Helpful

Peptide Therapy

Peptides are short chains of amino acids that can have various effects on the body. Some peptides, like growth hormone-releasing peptides (GHRPs) and CJC-1295, may enhance muscle growth, fat loss, and overall well-being when combined with TRT.

Primo (Primobolan)

Primobolan is an anabolic steroid that is often considered mild and estrogen-neutral. It can provide additional anabolism without the side effects associated with raising testosterone doses. Primobolan is a good choice for those seeking a subtle boost during TRT.

Nandrolone (Deca/NPP)

Nandrolone is another anabolic steroid that can be added to TRT. It’s known for joint support, favorable dosing, and maintaining muscle fullness. However, individual responses vary, so it’s essential to monitor how your body reacts.

Drostanolone propionate

Masteron supports high-intensity training during TRT by impacting the nervous system. It may help you push more weight and maintain muscle quality during cruises.

Dehydroepiandrosterone

Dehydroepiandrosterone (DHEA) is a natural hormone that declines with age. Some people find that supplementing with DHEA improves energy, mood, and overall well-being when combined with TRT.

Oxandrolone

Anavar is an oral steroid that can enhance muscle growth and strength. It’s often used during TRT for its anabolic properties.

Tadalafil

Tadalafil is commonly used for erectile dysfunction, but it also promotes blood flow to muscles. Some people take it daily to reduce inflammation and potentially raise testosterone levels.

Remember that individual responses to these compounds can vary, and it’s essential to consult with a healthcare professional before adding any substances to your TRT protocol.

Must Read: The Importance of Scaptions in Female Athletes

Dietary Considerations While on TRT

When you’re on testosterone replacement therapy (TRT), following a proper diet is essential for optimal results. Here are some dietary considerations to keep in mind:

Exercise Regularly: Although not directly related to diet, regular exercise is crucial for maximizing the benefits of TRT. Aim for weightlifting or resistance training 3 to 4 times a week, along with cardio exercises on non-weightlifting days.

Prioritize Protein: Protein supports muscle growth and repair. Aim for 0.7 to 1 gram of protein per pound of body weight daily. Include lean meats, fish, poultry, and quality protein supplements like casein or whey.

Pre-Workout Nutrition: Consume a high-protein, high-carbohydrate meal about two hours before your workout. If time is limited, have a protein drink an hour before exercising. After your workout, opt for a protein-rich meal with simple carbohydrates (rice, potatoes, pasta).

Health-Promoting Supplements: Consider supplements like Coenzyme Q10, Vitamin D3, Vitamin B-12, Creatine, Curcumin, Resveratrol, Fish Oil, and Glucosamine/Chondroitin. These can complement TRT and overall health.

Fiber Intake: Aim for at least 20 grams of fiber daily from sources like beans, vegetables, fruits, oatmeal, and whole-grain bread.

Remember, these guidelines apply to everyone, not just those on TRT. Prioritize a balanced diet, stay hydrated, and avoid excessive sugar and alcohol intake to optimize your health and fitness goals while on TRT.

Maintaining Optimal Hormonal Balance While on TRT

To maintain optimal health while on TRT, regular lab testing is crucial. Monitoring specific health markers helps guide your treatment. Here are the key markers to keep an eye on:

Total and Free Testosterone: Aim for an upper-normal range.

Estrogen Levels: Excess estrogen can lead to unwanted side effects.

Complete Blood Count (CBC): This test checks for elevated red blood cell count.

Liver Enzymes: Ensures your liver is handling TRT properly.

Lipid Profile: Monitors cholesterol levels.

PSA (Prostate-Specific Antigen): Screen for prostate cancer risk if you’re over 50.

Before starting TRT, get baseline blood work done. Then repeat it at 4-6 weeks and every 3-6 months once your levels stabilize. Frequent testing provides valuable insights to fine-tune your TRT protocol and optimize how you feel.

Overall

Testosterone Replacement Therapy (TRT) can be a powerful tool for bodybuilders, but it requires careful consideration. TRT stands for Testosterone Replacement Therapy. It’s a medical treatment used to address low testosterone levels. Administered through injections, patches, gels, or pellets, TRT helps restore testosterone levels to a healthier range. Benefits include improved muscle strength, energy levels, and overall well-being. Bodybuilders often use testosterone differently than standard TRT protocols. While TRT can enhance muscle growth, it’s not typically enough for IFBB pro bodybuilding competition.

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Typical dosages for bodybuilding range from 200 to 1000 milligrams per week. The benefits include enhanced muscle growth, improved energy levels, and increased libido. However, it’s essential to remember that TRT should always be supervised by a healthcare professional. If you’re considering it, consult with a specialist to determine if it’s the right choice for you!

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Anabolic Steroids

Peptides Vs. Steroids:Real Talk/Guide

Published

2 weeks ago

May 6, 2024

SaneNt

Many bodybuilders are unable to distinguish peptides from regular steroids. In this article we're going to explore Peptides vs. Steroids from various perspectives.

Let’s delve into the differences between peptides and steroids.

Mechanism of Action

- Peptides: These are short chains of amino acids. Peptides work by binding to specific receptors on the cell surface. They initiate signal transduction pathways, which activate various cellular processes. Peptides do not directly affect DNA or gene expression.
- Steroids: Steroids, on the other hand, penetrate the cell membrane and bind directly to DNA within the cell nucleus. They act as transcription participants, modifying gene expression.

Natural vs. Unnatural Effects

- Peptides: Peptides enhance natural processes in the body. For example, some peptides stimulate growth hormone release, improve recovery, and promote anti-aging effects.
- Steroids: Anabolic steroids artificially increase testosterone levels. They can be used for hormone replacement therapy but may have side effects due to their unnatural impact on the body.

Related Article: Oral Primobolan Cycle

Binding Sites

- Peptides: Bind to cell surface receptors.
- Steroids: Bind to receptors inside the cell cytoplasm and modify transcription.

Applications

- Peptides:
  - Weight Loss: Certain peptides can aid weight management.
  - Recovery & Repair: Peptides like BPC-157 support tissue healing.
  - Anti-Aging: Some peptides have skin-rejuvenating properties.
  - Reproductive Health: Peptides like kisspeptin-10 may impact reproductive health.
  - Cognitive Enhancement: Selank and semax are nootropic peptides.
- Steroids:
  - Hormone Replacement: Used for male hypogonadism (low testosterone).
  - Muscle Building: Anabolic steroids promote muscle growth.
  - Performance Enhancement: Athletes sometimes misuse steroids for performance gains.

Peptides Vs. Steroids Risk Profile

- Peptides: Generally considered safer with fewer side effects.
- Steroids: Higher risk of adverse effects, including liver damage, cardiovascular issues, and hormonal imbalances.

Peptides Vs. Steroids Dosages

Peptides

Dosages vary based on the specific peptide and desired effect.

Let’s explore the dosages for various peptides commonly used in bodybuilding. Remember that individual responses may vary, so always consult with a healthcare professional before starting any peptide regimen.

CJC-1295 and Ipamorelin Stack

CJC-1295

Typical Dosage: 1000 mcg to 2000 mcg per week.

Cycle Duration: 8 to 12 weeks (60 to 90 days).

Ipamorelin

Typical Dosage: 200 mcg to 300 mcg per day.

Cycle Duration: Similar to CJC-1295 (8 to 12 weeks).

Average Cost: Approximately $49 (Prices may vary depending on the supplier and product concentration).

GHRP-6

Typical Dosage: 4-10 mg per week, divided into two doses per week.

Cycle Duration: 4-6 weeks, followed by a maintenance dose.

Benefits: GHRP-6 stimulates growth hormone release, aiding muscle growth and recovery.

BPC-157

Typical Dosage: Varies based on the specific purpose (e.g., injury recovery or muscle healing).

Cycle Duration: Often used for 4-6 weeks.

Application: BPC-157 accelerates tissue repair and supports muscle healing.

IGF-1 (Insulin-like Growth Factor)

Dosage: Typically administered subcutaneously.

Cycle Duration: Varies; consult with your personal trainer or healthcare professional.

Benefits: IGF-1 promotes local muscle growth and repair.

Steroids

Dosages depend on the steroid type and purpose (e.g., medical or athletic use).

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Let’s dive into a comprehensive guide on steroid dosages for bodybuilding. Keep in mind that individual responses can vary, and it’s crucial to consult with a healthcare professional before starting any steroid regimen. Here are some common dosages for various steroids

Must Read: Beginner Bulking Cycle

Beginner Steroid Cycles

Testosterone Cycle

Dosage: Typically ranges from 300 mg to 500 mg per week.

Cycle Length: Usually 8 to 12 weeks.

Rest Period: Allow at least 4 to 6 weeks between cycles.

Anavar (Oxandrolone) Cycle

Dosage: Around 20 mg to 50 mg per day.

Cycle Length: 6 to 8 weeks.

Purpose: Anavar is mild and suitable for beginners, promoting lean muscle gains and fat loss2.

Bulking Steroid Cycles

Dianabol (Methandrostenolone) Cycle

Dosage: Typically 20 mg to 50 mg per day.

Cycle Length: 4 to 6 weeks.

Benefits: Dianabol is known for rapid muscle growth and strength gains.

Anadrol (Oxymetholone) Cycle

Dosage: 50 mg to 100 mg per day.

Cycle Length: 4 to 6 weeks.

Purpose: Anadrol is potent for bulking and increasing red blood cell production.

Trenbolone Cycle

Dosage: Varies (typically 200 mg to 400 mg per week).

Cycle Length: 8 to 10 weeks.

Benefits: Trenbolone promotes muscle growth, strength, and fat loss.

Deca Durabolin (Nandrolone Decanoate) Cycle

Dosage: 200 mg to 400 mg per week.

Cycle Length: 8 to 12 weeks.

Stacking: Often combined with testosterone for synergistic effects.

Cutting Steroid Cycles

Winstrol (Stanozolol) Cycle

Dosage: 20 mg to 50 mg per day (oral) or 50 mg to 100 mg every other day (injectable).

Cycle Length: 6 to 8 weeks.

Purpose: Winstrol helps preserve lean muscle during cutting phases.

Primobolan (Methenolone) Cycle

Dosage: 400 mg to 600 mg per week.

Cycle Length: 8 to 10 weeks.

Benefits: Primobolan is mild, promotes quality muscle, and has minimal side effects.

Clenbuterol Cycle

Dosage: Varies (typically 20 mcg to 120 mcg per day).

Cycle Length: 2 weeks on, 2 weeks off.

Purpose: Clenbuterol aids fat loss and enhances metabolism.

Advanced Steroid Cycles

Anadrol / Testosterone / Trenbolone Cycle

Dosages: Varies based on individual tolerance and goals.

Stacking: Combining Anadrol, testosterone, and trenbolone for maximum effects.

Winstrol / Proviron / Trenbolone Cycle

Dosages: Tailored to advanced users and pro bodybuilders.

Stacking: Winstrol, Proviron, and trenbolone synergize for cutting and hardening.

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Natural Alternatives

- Peptides: Consider natural alternatives like collagen peptides for skin health or melatonin for sleep.
- Steroids: Natural alternatives include resistance training, proper nutrition, and rest.

Peptides Vs. Steroids Impact on Muscle Growth

Peptides

Lean Muscle Gain: Peptides promote lean muscle mass by stimulating protein synthesis.

Recovery: Faster recovery from intense workouts and injuries.

Anti-Catabolic Effects: Peptides prevent muscle breakdown.

Example: Imagine an athlete recovering from a muscle strain. BPC-157 administration accelerates tissue repair, aiding muscle growth.

Steroids

Rapid Muscle Hypertrophy: Steroids lead to significant muscle growth due to increased protein synthesis.

Increased Strength: Athletes using steroids experience enhanced performance in strength-based activities.

Improved Recovery: Steroids reduce muscle damage and inflammation.

Example: A bodybuilder using testosterone sees substantial gains in muscle size and strength during a bulking phase.

FDA Stance on Peptides Vs. Steroids

The FDA has closely examined the commercialization and utilization of specific peptides and steroids, expressing apprehensions about their safety and the absence of approval for numerous substances.

As a result, the FDA has prohibited the sale of several peptides formerly favored by bodybuilders and fitness enthusiasts due to their purported muscle-building and performance-enhancing attributes.

This regulatory measure emphasizes the significance of following lawful and secure protocols when contemplating peptides for enhancing muscle growth.

It is crucial for individuals to remain well-informed regarding the peptides that adhere to FDA guidelines, enabling them to make prudent and lawful decisions concerning their health and fitness routines.

Importantly, the legality of steroids and peptides varies among countries and jurisdictions. We recommend checking legality in your country before commencing your routine.

Also Read: Varicose Veins In Bodybuilders-Risk Factors and How to Mitigate Them

Overall

As observed, steroids and peptide therapies share certain similarities in their effects, including enhanced strength, improved endurance, and increased fat burning, which are often sought after by individuals aiming to enhance their physical performance and appearance.

However, while both can achieve these outcomes, the risks associated with steroids are considerably higher compared to peptides.

Fred Kyle, a Certified Peptide Specialist at the Etalaze, advises individuals to carefully consider the potential consequences of using steroids on their health before opting for them as a means to enhance performance.

For those seeking an extra boost to overcome performance plateaus or slumps, it's recommended to consult with a professional, preferably your personal trainer or physician.