Steroids

Steroids vs Peptides – PROs and CONs

Published

6 years ago

November 7, 2018

Paul

Steroids are synthetic drugs just like the natural hormones in the body. AAS (Anabolic Androgenic Steroids) is the type of steroids, which copy the effect of male hormones and testosterone; used by people to build muscles and to increase strength. AAS are different from corticosteroids, which are medically used to treat asthma. There are more than one meaning of steroid. There is a medicine that's name is “steroid,” which people take to reel asthma and skin problems. Steroids help to reduce stress and increase the growth of the body.

Do you know there are some illegal anabolic steroids? Yes, the artificially produced hormones like androgens (Male-type sex hormones in the body). Anabolic Steroids are in the form of pills, injections, or powders.

Athletes use Anabolic Steroids to increase their muscle strength and mass. Girls also use steroids to become stronger.

Supplements are also available which contain anabolic steroids. Promoted by the ads and through magazines. Legal and illegal supplements cause health problems. Some are banned in the United States, but some are legal until now. Children’s should not take steroid supplements, either they are present in the market because they are dangerous for health.

Functions of Steroids:

There are two varieties of steroids developed for medical treatments. One is Anabolic Steroids which you hear most and as we also discussed them. They behave like male sex hormones, and medically they are used for the treatment of problems like late puberty and muscles loss in patients who have cancer and AIDS.

Although they are used for building muscles yet, they used for the cure of allergic reactions and autoimmune diseases. For autoimmune diseases, especially Prednisone is suggested for treating lupus and arthritis. (it is a famous type of Corticosteroid).

Anabolic Steroids and Corticosteroids both can be injected muscularly, and they can be either taken orally or by scrubbing on the body. They use in the muscle’s growth. According to research, various kinds of anabolic steroids have been introduced.

Our muscles become hard due to work out because of the creation of micro-tears in muscles fibers. Muscles will restart growing, and with the repetition of this process, they ultimately become hard and colossal. In this regard, the anabolic steroid works best as they enhance the pace of muscle healing by preventing the breakdown of muscle tissues. It is preferable for the use of athletes.

Types of Steroids:

Commonly known as anabolic steroids:

Oral Steroids:

Dianabol
Oxandrin
Anadrol
Anavar

Injectable Steroids:

Deca-Durabolin ("Deca" for short)
Equipoise ("Eq" for short)
Testosterone
Durabolin
Dianabol ("Dbol" for short)
Trenbolone

Let’s discuss a few major types:

Dianabol (DBol) is hormone/organic compound used to increase the ability and working power of the human body. It is widely used for bodybuilding and said the basic of the bodybuilding’s Arnold Schwarzenegger time. Dbol took orally, and it is very poisonous/toxic for liver.

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Trenbolone Acetate is considered as the best hormone that a person can take either in the beginning or at any time. It is super diverse. Tren made as a veterinary supplement used to increase the size of animals.

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Anavar, an oral organic compound used by men and women. A modest steroid and di-hydro testosterone obtained, frequently prescribed by doctors for gaining weight. Anavar is a constructive metabolism rating 3–6x higher than average testosterone. Anavar used as an “initial” steroid because of fewer side effects and want of strong androgenic effects.

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Deca Durabolin is a derivative of Nandrolone. It is less harmful than testosterone. The reason for Deca popularity is bulking steroid and its minimal side effects.

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PROs of Steroids:

Steroids said as performance-enhancing drugs used to enhance natural body performance. Artificial steroids used for the growth of reproductive organs, bones, body, hair, and muscles, proved by research.

Stamina Testosterone steroids used to improve the stamina for physical activities of athletes or fitness enthusiasts.

Weight Organic compounds are used to increase body weight and change shape, so it is widely used by sportsmen to shape their body.

Remedies - Steroids are used by athletes to cure their minor injuries or accidents because it has remedial effects.

Cons of Steroids:

Any invention has side effects and risk involvement, so steroids also have side effects. These steroids boost the performance than standard capacity.

Addiction If a person uses steroids daily then he became an addict of those because the chemical effects on his body, the steroids boost the working ability of body than natural capacity, so the person prefers to go for steroids further because he became used to with those organic compounds.

Infertility The human body stops producing natural hormones, or it produces fewer hormones as compare to previous hormones when chemical hormones are uses too much so over usage of organic compound cause infertility.

Health Steroids affect other body functions along with the purpose of their usage; they cause high cholesterol level, which increases the risk of heart diseases, high blood pressure, and over-weight.

Withdrawal If a regular user of steroids wants to get rid of steroids and he stops using it suddenly, then the person may be feeling lazy, weak, depression, nausea, nervous break-down or body pains. Therefore, the natural body way of performance can change by a steroid.

What are Peptides?

Peptides are protein in nature. They compile two or more amino acids which link together to form an amide. This linkage is covalent in the environment and formed between an amino acid (via a carboxyl group) and another amino acid (through nitrogen ending).

The primary difference between protein and peptides lies in the altering number of amino acids. When two amino acids covalently bond, they will form dipeptides. Many multi proteins bond together they will be called as Polypeptide, which contains 10-50 amino acids residues are commonly known as peptides. The protein number can go up to 50.

Most of the time, synthetic peptides we can see in the form of pharmaceutical products that includes some essential hormones as well as such as steroids, calcitonin, oxytocin, and adrenocorticotropic hormone. Based on various application and needs, the peptide has incurred multiple forms. Similarly, in different branches of biology, they are learning for different purposes.

Such as in cell biology, when they bind on the base of the receptor, they develop a new form commonly called enzymes. Now, these natural forms can replace with synthetic ones — for instance, the drugs used for treating cancer.

Some other uses of synthetic peptides have also come forward like they are used as reagents and standards in mass spectrometry (MS)-based applications. They play a vital role in terms of quantitation and characterization of proteins as well as biomarkers in many diseases. As far as the synthesis of peptides is concerned, they are significant for two ways of formation, solid-phase Fmoc peptide synthesis (SPPS) and liquid-phase peptide synthesis.

Peptide Bond:

It is a chemical bond which formed when two molecules bind together in a way that the amino group of one molecule reacts with the carboxyl group of one molecule reacts and as a result, it releases one molecule of water (H2O). Due to the release of the water molecule, this reaction is called a condensation reaction or dehydration synthesis reaction. The bond of a carboxyl group and amino group together makes a relationship which calls a peptide bond, and the consequential molecule calls as an amide.

Types of Peptides:

In this article, we will briefly discuss a few types of peptides which are given below:

Dipeptides HGH Fragment:

It formed because of the reaction between two amino acids forming one peptide bond. For example; Anserine (β-alanyl-N-methylhistidine) and Carnosine (β-alanyl-L-histidine).

Tripeptides:

This compound will form because of a reaction between 3 molecules of amino acids, and as a result, they will create 2 peptide bonds. For examples; Ophthalmic acid (L-γ-Glutamyl-α-L-amino butyral-glycine) and Glutathione (Glutamyl-cysteinyl-glycine)

Oligopeptide: When amino acids in a range of 2-20 are chemically bonded through the peptide bond; as a result, the Oligopeptides will form. For example; Amanitin (Decapeptide) and Tetrapeptide; Tulfsin (threonine-lysine-proline-Arginine).
Polypeptides When a peptide bond links more than 20 amino acids, the polypeptides will form — for example, Growth hormone and insulin.

Functions of Peptides:

Following are the features of the peptide in a human body:

Structural Functions In a human body, the main structure, formed of protein. Such as they compose the external membrane of every cell in the body, together they made human hair, skin, muscles, organs, and even tissues.
Driving Biochemical Reaction The essential items that run the biochemical reactions in a human body are enzymes. And enzymes are protein in nature. Enzymes act as a pacemaker in chemical reactions occurring in the human body. The most common examples are a chemical reaction in the nervous system, breathing, and digestion. Especially in terms of metabolism, where a series of biochemical reactions to convert food into energy.

Hormonal Regulation

Hormonal Regulation is the vital parts of the human body, which also make up of peptides. If a human body lacks the proper number of peptides in hormones it can even lead to severe cases such as puberty. They can even severely affect the other process, such as the production of sperm, menstrual cycle, and fertility in females. Other than this they are the determinants of the aging process, metabolism, regulate muscle mass, regulate moods and hair growth
Regulation of Cell Division either mitosis or meiosis, none can run with the peptides/protein deficiency. They replace the replenished cells and form new ones. There can be a different cause of cell damage such as exposure to the sun, chemical, and pollution. When a battery dies, the healthy one divides into two along with regulation through peptides. Upon a lack of protein leads to failure of cell growth, ultimately causing tumor growth and cancer.
Immune System Actions Antibodies are all, and all made up of peptide structure. They are highly essential for maintaining health and keeping the immune system healthy. Antibodies fight against virus and bacteria. Although the basic structure of the peptide in the antibody may differ, yet the presence of peptides. Antibody plays a communicative role, after detecting the invading germ the keep the immune system alert and helps to destroy the invader.

Pros of Peptides:

Let’s discuss a few general advantages f peptides:

Copies of the synthetic peptide can make easy for the human to fight against disease like cancer.
It has less percentage of toxicity as it lacks external proteins and nucleic acid.
Used in various anti-aging creams.
Best in use for anti-microbial treatments.
Essential component that forms the new skin at the place of disrupted one.
Helps to perform several essential body functions such as enzymes to speed up reactions, antibodies for the immune system, upon breakage produce water molecule in the body, hormones control the various functions even including sexual development in both males and females. All these functions are not possible without peptides.
Similar to nature peptides in a human body, science has reached levels where it can even synthesize the peptides in form or drugs as well as use them in the various diagnostic tool.

Cons of Peptides:

Let’s discuss a few disadvantages of the peptides as well:

As it is a part of various types of cells such as T cell epitopes, so in their absence, they will adversely affect the system of elicit cell-mediated immunity (CMI).
Peptides may assume less immunogenic that compared to conventional as it causes inactivation of whole-virus vaccines.
It will require adjuvant, which means, a substance that a body needs to enhance the immune system.

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Related Topics:Peptide Hormones peptides Peptides vs Steroids Pros And Cons

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Tips on How to Store Peptides and HGH

Published

4 days ago

January 9, 2025

Sane

When peptides are mixed with bacteriostatic water (BAC water), their longevity is highly influenced by how they are stored. Correct storage is crucial, as improper conditions can compromise their quality and reduce their efficacy.

Explore: Hypertrophy Training Program

Key Storage Guidelines

Room Temperature: Peptides tend to degrade rapidly at room temperature, lasting only a few hours to a day. It's best to use them immediately in this condition.

Refrigeration (2-8°C): When stored in a refrigerator, peptides mixed with BAC water can remain stable for 2-4 weeks. However, some peptides may degrade more quickly than others, so limiting storage to around two weeks is safest.

Freezing (-20°C or lower): For prolonged storage, freezing is the best option, maintaining peptide stability for several months. It is important to avoid multiple cycles of thawing and refreezing, as this can degrade the peptides.

It's important to note that storage guidelines can differ depending on the specific peptide, so always check for the particular recommendations to ensure maximum longevity and effectiveness.

NOTE: Peptides reconstituted with Sterile Water only remain potent for 2-3 days, even under ideal storage conditions. This is because sterile water lacks the antibacterial properties of BAC water, leading to faster bacterial growth and peptide degradation.

Finding Containers to Store Peptides and HGH

You can find containers for storing peptides and HGH at various online retailers and specialty stores. Here are a few options:

Edge Peptides: They offer a range of storage containers suitable for peptides, including glass and high-quality plastic vials.

Peptide Sciences: This site provides information on peptide storage and offers appropriate containers.

Muscle and Brawn: They have guidelines on peptide storage and sell containers designed for this purpose.

Make sure to choose containers that are chemically inert, such as glass or high-quality plastic, to avoid any reactions with the peptides. Additionally, ensure the containers are tightly sealed to prevent contamination and degradation.

What Would Be the Best Peptides and HGH for Beginners?

For beginner bodybuilders and athletes, it's important to start with safe and effective options. Here are some of the best peptides and human growth hormone (HGH) supplements:

Peptides for Muscle Growth

Ipamorelin: Stimulates growth hormone production, aiding muscle growth and fat loss.

CJC-1295: Enhances growth hormone release, promoting muscle growth and improving sleep quality.

Hexarelin: Stimulates growth hormone release, aiding muscle gain and cardiovascular health.

Sermorelin: Increases growth hormone production, beneficial for muscle growth.

GHRP-6: Stimulates growth hormone release, increasing energy levels and aiding muscle growth.

HGH Supplements

CrazyBulk HGH-X2: Boosts HGH production, increases energy levels, and helps build muscle mass.

HyperGH 14x: Promotes muscle growth and improves performance.

GenF20 Plus: Maintains optimal HGH levels, aiding in muscle growth and anti-aging.

PGH-1000: Enhances strength and stamina.

Sytropin: Supports physical fitness, anti-aging, and andropause.

Summary

Storing peptides and human growth hormone (HGH) properly is crucial for maintaining their effectiveness and ensuring safety. Peptides should ideally be stored in a refrigerator at 2-8°C for up to 2-4 weeks when mixed with bacteriostatic water, while freezing them at -20°C or lower extends their stability for several months, but avoid thawing and refreezing. When reconstituting peptides, use bacteriostatic water instead of sterile water to maintain potency for a longer duration (2-4 weeks versus 2-3 days). Use chemically inert containers, like glass or high-quality plastic vials, and ensure they are tightly sealed. Maintain sterility during reconstitution and storage to prevent bacterial contamination.

Use reconstituted peptides as soon as possible to avoid degradation in solution. Popular peptides for muscle growth include Ipamorelin, CJC-1295, Hexarelin, Sermorelin, and GHRP-6, while CrazyBulk HGH-X2 is a common supplement to boost HGH production. Always check the specific storage recommendations for each peptide, as they can vary.

Remember, it's crucial to consult with a healthcare professional before starting any new supplement regimen to ensure it's safe and appropriate for your individual needs.

Must Read: Targeted Training for Individual Muscle Groups

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Steroids

Ostarine For Beginners: The Ultimate Guide

Published

2 weeks ago

December 29, 2024

Sane

Ostarine, also referred to as MK-2866 or Enobosarm, is among the most extensively used and researched Selective Androgen Receptor Modulators (SARMs). Initially developed to combat muscle-wasting diseases, it has gained immense popularity among athletes and bodybuilders for its muscle-preserving and performance-enhancing benefits.

How Does It Work?

Ostarine selectively binds to androgen receptors in muscle and bone tissues, promoting protein synthesis and osteogenesis. Unlike anabolic androgenic steroids (AAS), which interact with androgen receptors throughout the body, Ostarine specifically targets certain tissues, reducing the risk of unwanted side effects such as hair loss, high estrogen levels, prostate enlargement, or virilization in women.

Practical Benefits of Ostarine

Muscle Preservation

Ostarine is well-known for its ability to maintain lean muscle mass, especially during calorie deficits. Studies have shown that it prevents muscle wasting while sustaining strength and endurance, making it ideal for cutting cycles (Dalton et al., 2011).

Muscle Growth

Although its muscle-building capacity is milder compared to stronger SARMs or AAS, Ostarine effectively promotes gradual, high-quality muscle gains without excessive water retention.

Improved Recovery

Athletes have reported enhanced recovery times with Ostarine. By reducing muscle breakdown and increasing nitrogen retention, it allows users to train more frequently and intensively.

Bone Health

Ostarine positively impacts bone density. Research indicates its ability to increase bone mineralization, potentially making it a therapeutic agent for osteoporosis (Narayanan et al., 2008). For athletes, this translates to a reduced injury risk and stronger skeletal support during heavy training.

Related Article: Legality of Steroids in Latin America

Potential Side Effects

Mild Testosterone Suppression

Ostarine can suppress natural testosterone production, particularly at higher doses. Post Cycle Therapy (PCT) is recommended after cycles to restore hormonal balance.

Dyslipidemia

Like most SARMs, Ostarine can affect lipid profiles, potentially lowering HDL (good cholesterol) and increasing LDL (bad cholesterol).

Elevated Liver Enzymes

Some users report mild elevations in liver enzymes during use, though these usually return to normal after discontinuation.

Long-Term Effects

Unknown As a relatively new compound, the long-term effects of Ostarine on health are not fully understood.

How to Use Ostarine Correctly

Dosage and Cycle Recommendations

Ostarine is typically dosed at 10–30 mg per day, depending on the user’s goals and experience level:

For Cutting: 10–20 mg per day to preserve muscle and aid fat loss.

For Bulking: 20–30 mg per day to promote lean muscle gains.

Cycles generally last 6–8 weeks. Longer cycles or higher doses may increase the risk of side effects, including testosterone suppression. With a half-life of approximately 24 hours, Ostarine allows for convenient once-daily dosing.

Post Cycle Therapy (PCT)

We highly recommend PCT following Ostarine cycles, especially for doses exceeding 20 mg per day, to restore natural testosterone levels.

Ostarine Alternatives

For beginner bodybuilders looking for alternatives to Ostarine, here are some popular options:

RAD 140 (Testolone): Known for its excellent muscle-building and fat-burning properties, RAD 140 is a favorite among those looking to gain lean muscle mass.
LGD-4033 (Ligandrol): This SARM is highly effective for increasing strength and muscle mass, making it a great choice for beginners.
Cardarine (GW-501516): Although not technically a SARM, Cardarine is popular for its ability to enhance endurance and fat loss.
YK-11: This SARM is known for its ability to promote muscle growth and strength, similar to anabolic steroids.
S23: Effective for cutting cycles, S23 helps reduce body fat while preserving muscle mass.
Andarine (S4): This SARM is used for both bulking and cutting, offering muscle preservation and fat loss.

These alternatives offer various benefits and can be chosen based on individual goals and preferences. It's always important to research and consult with a healthcare professional before starting any new supplement regimen.

Check Out: Popular Fitness Apps

Overall

Ostarine (MK-2866) is a versatile and beginner-friendly SARM, offering significant benefits for muscle preservation, recovery, and lean growth. Its selective action and mild side-effect profile make it an attractive option for athletes and bodybuilders seeking an edge in performance and aesthetics. However, responsible use, including appropriate dosing, cycle length, and post-cycle therapy, is crucial to minimizing risks and maximizing results.

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Steroids

Mushroom Chitosan for Skin Care: A Plant-Based Option for Skincare

Published

3 weeks ago

December 23, 2024

Sane

Mushroom chitosan is a prominent ingredient in the skincare industry, celebrated for its compatibility with skin, moisturizing properties, and its role in wound healing and skin regeneration. Extracted from the cell walls of specific mushrooms, this eco-friendly, plant-based alternative to traditional chitosan (which is typically derived from shellfish) has recently gained considerable attention. It is swiftly becoming a favored ingredient in products designed to enhance skin texture, reduce inflammation, and improve moisture retention. This article delves into the science behind mushroom chitosan, its skin benefits, and how it compares to other popular ingredients.

Chitosan Overview

Chitosan is a natural polysaccharide traditionally obtained from the exoskeletons of shellfish like shrimp and crabs. However, mushroom chitosan, derived from fungi such as Aspergillus niger and Agaricus bisporus, offers a plant-based, vegan-friendly alternative. It provides similar benefits without the allergens or ethical concerns associated with animal-derived ingredients.

What It Does

Mushroom chitosan exhibits excellent biocompatibility, meaning it works well with human skin without causing irritation or allergic reactions. It is also biodegradable and sustainable, making it a particularly appealing option for eco-conscious consumers.

Mushroom chitosan forms a protective film on the skin’s surface, which helps retain moisture and shields the skin from environmental stressors like pollution and harmful bacteria. This barrier function also enhances the skin’s ability to retain water, making it especially beneficial for individuals with dry or sensitive skin.

Chitosan Magic

Additionally, chitosan has antimicrobial properties that can help prevent and treat skin infections. It promotes wound healing by accelerating the regeneration of skin cells, making it useful for post-inflammatory conditions like acne scars or minor cuts. Here is a summary of the main benefits of using mushroom chitosan:

Enhanced Hydration

Mushroom chitosan’s film-forming ability helps lock in moisture, maintaining the skin’s hydration levels. This is especially beneficial for dry, dehydrated skin or for maintaining a healthy moisture barrier.

Anti-inflammatory

Chitosan has been shown to reduce inflammation, which can soothe irritated or red skin. This makes it effective for people dealing with sensitive skin conditions like eczema or rosacea.

Chitosan Wound Healing and Skin Repair

Studies have shown that chitosan accelerates the skin’s natural healing process, making it a valuable ingredient for wound care and the recovery of damaged skin. It supports the regeneration of healthy skin cells, which can help minimize scarring and promote overall skin health.

Chitosan Antimicrobial Properties

Its ability to inhibit the growth of bacteria and fungi can help reduce breakouts and skin infections, providing a natural solution for acne-prone skin.

Anti-aging Benefits

Mushroom chitosan supports the skin’s elasticity and firmness by maintaining moisture levels and protecting it from oxidative stress, making it an effective anti-aging ingredient. By reducing the appearance of fine lines and improving texture, it contributes to a smoother, youthful complexion.

Related Article: Why A Newbie Must Use Electrolytes

Let's Compare it With Traditional Skin Products

Hyaluronic Acid: Mushroom chitosan and hyaluronic acid are both excellent for retaining moisture in the skin. However, chitosan also offers antimicrobial and wound-healing benefits, making it a multifunctional ingredient.

Collagen: Both ingredients aim to improve skin texture and elasticity. While collagen helps firm and plump the skin, mushroom chitosan focuses on moisture retention, repair, and protective qualities, offering a more comprehensive approach to skincare.

Traditional Chitosan: Mushroom chitosan has an edge over traditional shellfish-derived chitosan as it is plant-based and hypoallergenic. People with shellfish allergies can use it safely, and it’s also suitable for vegans and those seeking sustainable skincare options.

Main Products Containing Mushroom Chitosan

Moisturizers and Serums: As a potent humectant, mushroom chitosan is increasingly used in moisturizing products to boost skin hydration, enhancing the skin’s natural barrier.

Acne Treatments: Thanks to its antimicrobial and anti-inflammatory properties, mushroom chitosan is an excellent ingredient in acne-fighting formulas, reducing bacterial growth while calming inflamed skin.

Wound Healing Creams: Given its regenerative abilities, mushroom chitosan is often included in creams designed to speed up wound healing or reduce scarring, especially for acne-prone skin or post-skin procedures.

Anti-aging Products: Mushroom chitosan’s ability to retain moisture and support the skin’s elasticity makes it a key ingredient in anti-aging serums and creams, helping to reduce the appearance of fine lines and wrinkles.

Overall

Mushroom chitosan is an exciting, versatile ingredient in skincare that addresses multiple concerns, from hydration and inflammation to skin repair and protection. As a vegan-friendly, eco-conscious alternative to traditional chitosan, it offers a sustainable and effective solution for enhancing skin health. With its broad range of benefits and gentle nature, mushroom chitosan is poised to become a staple in modern skincare.

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